Wei Xiaojie, Yang Haojun, Dang Ruochen, Hu Bingliang, Feng Li, Xie Yuanyuan, Wang Quan
Key Laboratory of Spectral Imaging Technology, Xi'an Institute of Optics and Precision Mechanics (XIOPM), Chinese Academy of Sciences, Xi' an 710119, China.
University of Chinese Academy of Sciences, Beijing 101408, China.
Bioengineering (Basel). 2025 Apr 4;12(4):387. doi: 10.3390/bioengineering12040387.
Existing studies have shown that the attentional function of epilepsy is prone to be impaired. However, the characterization of brain connectivity behind this impairment remains uncertain. This study investigates attention-related brain connectivity in 92 patients with temporal lobe epilepsy and 78 healthy controls using a 32-channel EEG monitor during an attention network test. Compared to controls, patients showed reduced temporal-occipital connectivity in the alerting and orienting networks, but increased frontal-occipital connectivity in the executive network. Additionally, this study showed that patients and healthy individuals exhibited similar network topologies in the alerting and orienting networks, but the executive networks in patients showed altered topology properties, with a larger clustering coefficient in the theta band and a longer characteristic path length in the delta and theta bands. These findings reveal distinct characteristics of attention network connectivity in patients with temporal lobe epilepsy, offering valuable insights into the underlying mechanisms of epilepsy and providing clinical guidance for long-term monitoring and intervention.
现有研究表明，癫痫患者的注意力功能容易受损。然而，这种损伤背后的脑连接特征仍不明确。本研究使用32通道脑电图监测仪，在注意力网络测试期间，对92例颞叶癫痫患者和78名健康对照者的注意力相关脑连接进行了研究。与对照组相比，患者在警觉和定向网络中颞枕连接减少，但在执行网络中额枕连接增加。此外，本研究表明，患者和健康个体在警觉和定向网络中表现出相似的网络拓扑结构，但患者的执行网络表现出拓扑属性改变，在θ波段聚类系数更大，在δ和θ波段特征路径长度更长。这些发现揭示了颞叶癫痫患者注意力网络连接的独特特征，为癫痫的潜在机制提供了有价值的见解，并为长期监测和干预提供了临床指导。
