Department of Radiation Oncology, Vancouver Island Centre, BC Cancer Agency, Victoria, British Columbia, Canada.
Clin Cancer Res. 2012 Sep 1;18(17):4522-5. doi: 10.1158/1078-0432.CCR-12-1175. Epub 2012 Jul 3.
Clinical results indicate improved survival in poorly differentiated prostate cancer patients following a treatment schedule that maximizes hormone therapy prior to radiation. This may be because of a systemic immune response, called an abscopal effect. A literature review showed an association between acute infection and abscopal cancer remission. This led to the theory that, in the presence of endogenous cancer-specific antigens exposed by cancer necrosis, an innate immune response can adapt to respond to those antigens via a cross-talk mechanism. This theory was validated in an animal model. An acute innate immune T-cell response was stimulated using cluster vaccination with Poly(I:C). In the presence of exogenous cancer-specific antigens, this immune response became adaptive, creating an abscopal effect that resulted in cancer resolution. These concepts may be of clinical value, improving outcomes by inducing systemic abscopal effects.
临床结果表明，在最大限度地进行激素治疗以辅助放疗的治疗方案下，低分化前列腺癌患者的存活率得到了提高。这可能是由于全身性免疫反应，即远隔效应。文献综述表明，急性感染与远隔肿瘤缓解之间存在关联。这就产生了一种理论，即在肿瘤坏死暴露的内源性肿瘤特异性抗原存在的情况下，先天免疫反应可以通过交叉对话机制来适应这些抗原。该理论在动物模型中得到了验证。通过使用 Poly(I:C) 进行聚类疫苗接种来刺激急性先天免疫 T 细胞反应。在外源肿瘤特异性抗原存在的情况下，这种免疫反应会变得具有适应性，从而产生远隔效应，导致肿瘤消退。这些概念可能具有临床价值，通过诱导全身性远隔效应来改善治疗效果。
