干扰素基因刺激因子对皮肤癌的调控

Modulation of Skin Cancer by the Stimulator of Interferon Genes.

作者信息

Oscherwitz Max, Jiminez Victoria, Terhaar Hanna, Yusuf Nabiha

机构信息

Heersink School of Medicine, University of Alabama, Birmingham, AL 35294, USA.

Department of Dermatology, University of Alabama, Birmingham, AL 35294, USA.

出版信息

Genes (Basel). 2023 Sep 13;14(9):1794. doi: 10.3390/genes14091794.

DOI:10.3390/genes14091794

PMID:37761934

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10530941/

Abstract

Morbidity and mortality from skin cancer continue to rise domestically and globally, and melanoma and non-melanoma skin cancers are a topic of interest in the dermatology and oncology communities. In this review, we summarize the stimulator of interferon genes (STING) pathway, its specific role in the pathogenesis of DNA damage and skin cancer, and STING-specific therapies that may fight both melanoma and non-melanoma skin (NMSC) cancers. Furthermore, we discuss specific portions of the STING pathway that may be used in addition to previously used therapies to provide a synergistic effect in future oncology treatments and discuss the limitations of current STING-based therapies.

摘要

皮肤癌的发病率和死亡率在国内和全球范围内持续上升，黑色素瘤和非黑色素瘤皮肤癌是皮肤科和肿瘤学界关注的话题。在这篇综述中，我们总结了干扰素基因刺激因子（STING）通路、其在DNA损伤和皮肤癌发病机制中的具体作用，以及可能对抗黑色素瘤和非黑色素瘤皮肤癌（NMSC）的STING特异性疗法。此外，我们还讨论了STING通路的特定部分，这些部分除了可与先前使用的疗法联合使用外，还可能在未来的肿瘤治疗中产生协同效应，并探讨了当前基于STING疗法的局限性。