Shah Mitanshu, Prasad Apsara, Rajan Dhyan, Tan Christopher B, Shah Mansi, Raghavan Pooja, Mustacchia Paul
Department of Internal Medicine, Nassau University Medical Center, East Meadow, NY 11554, USA.
Case Rep Med. 2012;2012:651232. doi: 10.1155/2012/651232. Epub 2012 Jun 17.
Gastric cancer often carries a poor prognosis, with an estimated 740,000 deaths from the malignancy occurring yearly worldwide (Dicken et al., 2005). The mortality of disease is largely dependent on the extent of tumor spread, as gastric cancer has a predilection to metastasize to other visceral secondaries via hematogenous and lymphatic dissemination. Direct invasion of a gastric adenocarcinoma to adjacent organs secondary to gastric wall perforation does occur; however, it is often present in the setting of advanced disease. Rarely does direct tumor invasion to adjacent organs from a gastric adenocarcinoma present as the initial manifestation of extranodal tumor spread. We present a case of a 40-year-old male with direct tumor extension to the liver as an initial presentation of extranodal tumor spread from a gastric adenocarcinoma. Clinicians should be aware of such an occurrence, as treatment modalities in direct liver extension from a gastric adenocarcinoma vary and may be directed towards palliation rather than curative intent.
胃癌的预后通常较差,据估计全球每年有74万人死于这种恶性肿瘤(迪肯等人,2005年)。该疾病的死亡率很大程度上取决于肿瘤扩散的程度,因为胃癌倾向于通过血行和淋巴扩散转移至其他内脏继发性肿瘤。胃腺癌确实会因胃壁穿孔而直接侵犯相邻器官;然而,这种情况通常出现在疾病晚期。胃腺癌直接侵犯相邻器官作为结外肿瘤扩散的初始表现极为罕见。我们报告一例40岁男性,其胃腺癌以肿瘤直接蔓延至肝脏作为结外肿瘤扩散的初始表现。临床医生应意识到这种情况的发生,因为胃腺癌直接蔓延至肝脏的治疗方式各不相同,可能以姑息治疗而非根治为目的。