Department of Pharmaceutical Sciences, Guru Jmabheshwar University of Science and Technology, Hisar 125001, India.
Med Chem. 2013 Mar;9(2):249-74. doi: 10.2174/1573406411309020009.
A series of naphthalen-1-yl-acetic acid benzylidene/(1-phenyl-ethylidene)-hydrazides (1-36) was synthesized and tested, in vitro, for antiviral, antibacterial and antifungal activities. The antibacterial and antifungal screening results indicated that compounds having o-bromo, methoxy and hydroxy substitutents were the most active ones. The results of antiviral evaluation showed that none of the synthesized derivatives inhibited the viral infection at subtoxic concentrations. QSAR investigations revealed that the multi-target QSAR model was more effective in describing the antimicrobial activity than the one-target QSAR models. Further, it revealed the importance of the partition coefficient (log P) followed by energies of the highest occupied molecular orbital (HOMO) and topological parameters, molecular connectivity indices (1χ, 3χ and 3χv) in describing the antimicrobial activity of substituted hydrazides.
一系列萘-1-基-乙酸苄叉基/（1-苯基-亚乙基）-酰肼（1-36）被合成并进行了体外抗病毒、抗菌和抗真菌活性测试。抗菌和抗真菌筛选结果表明，具有邻溴、甲氧基和羟基取代基的化合物是最活跃的。抗病毒评估的结果表明，在所测试的浓度下，没有一种合成衍生物能抑制病毒感染。QSAR 研究表明，多靶点 QSAR 模型比单靶点 QSAR 模型更能有效地描述抗菌活性。此外，它还揭示了分配系数（log P）、最高占据分子轨道（HOMO）能量和拓扑参数、分子连接性指数（1χ、3χ 和 3χv）在描述取代酰肼的抗菌活性方面的重要性。
