Marmara University, Dental School, Department of Paediatric Dentistry, Istanbul, Turkey.
Eur J Paediatr Dent. 2012 Jun;13(2):123-7.
Casein phosphopeptide stabilised amorphous calcium phosphate (CPP-ACP) has been shown to remineralise enamel subsurface lesions. The aim of this study was to determine the effect of a paste containing 10% CPP-ACP (Toothmousse; GC) on enamel surface microhardness in vitro.
Thirty enamel blocks (3x2 mm) were prepared for the study group from the buccal surface of extracted teeth. The microhardness of the enamel surface was determined for the specimens initially before artificial demineralisation. After demineralization the specimens were incubated in 10% CPP-ACP for 5 min. Artificial saliva was used as a remineralising solution for the control group.
The mean baseline surface microhardness analyses of enamel blocks were 318.61±25.75 and 262.49±26.82. The data show that after demineralisation the mean microhardness decline in the experimental groups (247.05± 38.31 and 186.92± 63.77). The results showed that 10% CPP-ACP (281.79±26.32) was comparable to the control (252.27± 31.05) for remineralisation of enamel subsurface lesions in vitro. The highest surface microhardness recovery (%SMHR) was found for control, but the differences of % SMHR between 10% CPP-ACP and control was not statistically significant (p=0.805).
From the results it can be concluded that CPP-ACP may have positive effects on enamel remineralisation.
已证实酪蛋白磷酸肽稳定的无定形磷酸钙（CPP-ACP）能够使釉质表面下的龋损再矿化。本研究旨在确定含有 10％CPP-ACP（Toothmousse；GC）的糊剂对体外釉质表面显微硬度的影响。
从拔牙的颊面制备 30 个釉质块（3x2mm）用于实验组。在人工脱矿化之前，先对标本的釉质表面显微硬度进行初始测定。脱矿后，将标本在 10％CPP-ACP 中孵育 5 分钟。人工唾液被用作对照组的再矿化溶液。
釉质块的基线表面显微硬度分析的平均值分别为 318.61±25.75 和 262.49±26.82。数据表明，脱矿后实验组的平均显微硬度下降（247.05±38.31 和 186.92±63.77）。结果表明，10％CPP-ACP（281.79±26.32）与对照组（252.27±31.05）相当，可用于体外釉质表面下龋损的再矿化。控制组的表面显微硬度恢复率（%SMHR）最高，但 10％CPP-ACP 和对照组之间的%SMHR 差异无统计学意义（p=0.805）。
从结果可以得出结论，CPP-ACP 可能对釉质再矿化有积极作用。
