Department of Internal Medicine I, University of Regensburg, 93042 Regensburg, Germany.
Curr Drug Deliv. 2012 Jul;9(4):345-9. doi: 10.2174/156720112801323071.
Crohn's disease (CD) and ulcerative colitis (UC) represent two similar but probably not uniform entities of inflammatory bowel disease (IBD). Since up to now no curative treatment is available the therapeutic goal in active IBD is elimination or at least alleviation of symptoms and maintenance of remission. Glucocorticoids have been successfully used in the treatment of symptoms and inflammation. Due to the minor systemic side effects a topical drug delivery targeting the active substances directly to the inflamed sites would be the favorable administration. In this review the use of topical corticosteroids is discussed, based on a short description of their pharmacological properties.
克罗恩病（CD）和溃疡性结肠炎（UC）代表了炎症性肠病（IBD）的两种相似但可能并不相同的疾病实体。由于目前尚无治愈方法，因此活动性 IBD 的治疗目标是消除或至少缓解症状并维持缓解。糖皮质激素已成功用于治疗症状和炎症。由于其全身副作用较小，因此将靶向活性物质直接递送至炎症部位的局部药物递送将是有利的给药方式。在本文综述中，基于对其药理学特性的简短描述，讨论了局部皮质类固醇的使用。
