Kuwabara Y, Ichiya Y, Otsuka M, Tahara T, Fukumura T, Gunasekera R, Masuda K
Department of Radiology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Clin Nucl Med. 1990 Dec;15(12):893-9. doi: 10.1097/00003072-199012000-00009.
This report discusses the clinical significance of bilateral parietal abnormalities on I-123 IMP SPECT imaging in 158 patients with cerebral disorders. This pattern was seen in 15 out of 21 patients with Alzheimer's disease; it was also seen in 4 out of 5 patients with Parkinson's disease with dementia, in 3 out of 17 patients with vascular dementia, in 1 out of 36 patients with cerebral infarction without dementia, in 1 out of 2 patients with hypoglycemia, and in 1 out of 2 patients with CO intoxication. Detection of bilateral parietal abnormalities is a useful finding in the diagnosis of Alzheimer's disease, but one should keep in mind that other cerebral disorders may also show a similar pattern with I-123 IMP SPECT imaging.
本报告探讨了158例脑部疾病患者I-123异丁基异丙基胍单光子发射计算机断层扫描（SPECT）成像中双侧顶叶异常的临床意义。21例阿尔茨海默病患者中有15例出现这种模式；5例帕金森病伴痴呆患者中有4例出现这种模式，17例血管性痴呆患者中有3例出现这种模式，36例无痴呆的脑梗死患者中有1例出现这种模式，2例低血糖患者中有1例出现这种模式，2例一氧化碳中毒患者中有1例出现这种模式。双侧顶叶异常的检测在阿尔茨海默病的诊断中是一个有用的发现，但应记住，其他脑部疾病在I-123异丁基异丙基胍SPECT成像中也可能显示出类似的模式。
