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核磁共振成像和用放射性碘标记化合物的单光子发射断层扫描在痴呆症诊断中的应用

Nuclear magnetic resonance imaging and single photon emission tomography with radio-iodine labelled compounds in the diagnosis of dementia.

作者信息

Ebmeier K P, Besson J A, Crawford J R, Palin A N, Gemmel H G, Sharp P F, Cherryman G R, Smith F W

出版信息

Acta Psychiatr Scand. 1987 May;75(5):549-56. doi: 10.1111/j.1600-0447.1987.tb02832.x.

DOI:10.1111/j.1600-0447.1987.tb02832.x
PMID:3496733
Abstract

White matter lesions and T1 changes were identified using NMR and then compared between groups of patients suffering from dementia of the Alzheimer type (DAT), Multiple infarct dementia (MID) and normal controls. All DAT and MID patients were also imaged with a gamma camera using 123Iodo-n-isopropyl-amphetamine, a radiopharmaceutical whose uptake in the brain follows the regional blood flow. While NMR was not able to differentiate between DAT and MID, 19 out of 21 DAT patients compared to four out of 18 MID patients showed bilateral parietal lesions on IMP scans.

摘要

使用核磁共振成像(NMR)识别白质病变和T1变化,然后在患有阿尔茨海默型痴呆(DAT)、多发梗死性痴呆(MID)的患者组与正常对照组之间进行比较。所有DAT和MID患者还使用γ相机,通过123碘-n-异丙基安非他明进行成像,123碘-n-异丙基安非他明是一种放射性药物,其在大脑中的摄取遵循局部血流情况。虽然核磁共振成像无法区分DAT和MID,但在IMP扫描中,21例DAT患者中有19例与18例MID患者中的4例相比,显示出双侧顶叶病变。

相似文献

1
Nuclear magnetic resonance imaging and single photon emission tomography with radio-iodine labelled compounds in the diagnosis of dementia.核磁共振成像和用放射性碘标记化合物的单光子发射断层扫描在痴呆症诊断中的应用
Acta Psychiatr Scand. 1987 May;75(5):549-56. doi: 10.1111/j.1600-0447.1987.tb02832.x.
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The diagnosis of dementia with single photon emission computed tomography.基于单光子发射计算机断层扫描的痴呆症诊断
Arch Neurol. 1987 Mar;44(3):258-62. doi: 10.1001/archneur.1987.00520150014011.
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Variability of cerebral blood flow defects in Alzheimer's disease on 123iodo-isopropyl-amphetamine and single photon emission tomography.阿尔茨海默病中脑血流缺陷在123碘异丙基安非他明和单光子发射断层扫描上的变异性
Lancet. 1985 Jun 1;1(8440):1282. doi: 10.1016/s0140-6736(85)92357-8.
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Differential diagnosis of bilateral parietal abnormalities in I-123 IMP SPECT imaging.I-123异丁基腈肟基苯甲胺单光子发射计算机断层显像中双侧顶叶异常的鉴别诊断
Clin Nucl Med. 1990 Dec;15(12):893-9. doi: 10.1097/00003072-199012000-00009.
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Application of iodine-123-labeled isopropylamphetamine imaging to the study of dementia.
J Nucl Med. 1986 Jun;27(6):761-8.
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123I-N-isopropyl-amphetamine single photon emission computed tomography as a brain imaging technique in dementia.
Acta Radiol Suppl. 1986;369:460-2.
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[Regional cerebral blood flow and periventricular hyperintensity in silent cerebral infarction--comparison with multi-infarct dementia].无症状性脑梗死的局部脑血流与脑室周围高信号——与多发梗死性痴呆的比较
Rinsho Shinkeigaku. 1996 Jun;36(6):746-51.
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Diagnosis of Alzheimer's disease and multiple infarct dementia by tomographic imaging of iodine-123 IMP.通过碘-123 IMP断层成像诊断阿尔茨海默病和多发性梗死性痴呆。
J Nucl Med. 1986 Jun;27(6):769-74.
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A comparison of Tc-99m HM-PAO and I-123 IMP cerebral SPECT images in Alzheimer's disease and multi-infarct dementia.
Eur J Nucl Med. 1988;14(9-10):463-6. doi: 10.1007/BF00252389.
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Single photon emission tomography with 123I-isopropylamphetamine in Alzheimer's disease and multi-infarct dementia.
Lancet. 1984 Dec 8;2(8415):1348. doi: 10.1016/s0140-6736(84)90864-x.

引用本文的文献

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The appropriate use of neuroimaging in the diagnostic work-up of dementia: an evidence-based analysis.神经影像学在痴呆诊断检查中的合理应用:一项基于证据的分析。
Ont Health Technol Assess Ser. 2014 Feb 1;14(1):1-64. eCollection 2014.
2
Is MRI better than CT for detecting a vascular component to dementia? A systematic review and meta-analysis.MRI 比 CT 更能检测痴呆症的血管成分吗?系统评价和荟萃分析。
BMC Neurol. 2012 Jun 6;12:33. doi: 10.1186/1471-2377-12-33.
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Do white matter changes on MRI and CT differentiate vascular dementia from Alzheimer's disease?
磁共振成像(MRI)和计算机断层扫描(CT)上的白质变化能区分血管性痴呆和阿尔茨海默病吗?
J Neurol Neurosurg Psychiatry. 1988 Feb;51(2):318-9. doi: 10.1136/jnnp.51.2.318-a.
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Leukoaraiosis: a reappraisal. II. MRI studies.
Ital J Neurol Sci. 1991 Jun;12(3):271-9. doi: 10.1007/BF02337774.