Department of Advanced Clinical Science and Therapeutics, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8655, Japan.
Curr Top Med Chem. 2012;12(15):1608-12. doi: 10.2174/156802612803531478.
Although organ transplantations have been broadly performed in humans, occurrence of rejection has not yet been resolved. Several inflammatory factors, such as cytokines and adhesion molecules, enhance the rejection. Specific treatments that target in the attenuation of rejection have not been well studied in organ transplantation. Recent progress in the nucleic acid drugs, such as antisense oligodeoxynucleotides (ODNs) to regulate the transcription of disease-related genes, are known to play critical roles in therapeutic applications. Transfection of cis-element double-stranded DNA, named as "decoy", has been also reported to be a useful nucleic acid drug. This strategy has been not only a useful method for the experimental studies of gene regulation but also a novel clinical strategy. In this article, we reviewed the experimental results of nucleic acid drugs using the experimental organ transplant models.
尽管器官移植在人类中已经广泛开展，但排斥反应的发生仍未得到解决。几种炎症因子，如细胞因子和黏附分子，增强了排斥反应。针对器官移植中排斥反应的抑制作用的特定治疗方法尚未得到很好的研究。核酸药物的最新进展，如反义寡脱氧核苷酸（ODNs）来调节与疾病相关基因的转录，已被证明在治疗应用中起着关键作用。顺式元件双链 DNA 的转染，称为“诱饵”，也被报道是一种有用的核酸药物。这种策略不仅是基因调控实验研究的有用方法，也是一种新的临床策略。本文综述了使用实验性器官移植模型的核酸药物的实验结果。
