Department of Family Medicine, College of Medicine, Korea University, Seoul, Republic of Korea.
Nutr Metab Cardiovasc Dis. 2013 Aug;23(8):785-91. doi: 10.1016/j.numecd.2012.04.013. Epub 2012 Jul 3.
Evidence of the relationship between serum vitamin D levels and cardiovascular risk factors in children is limited. We investigated the associations between serum vitamin D levels (25-hydroxyvitamin D [25(OH)D]) and obesity and metabolic syndrome and its components in Korean children.
We recruited 1660, nine-year-old, Korean children (904 boys and 756 girls) who voluntarily participated in this study while being examined during school-based health examinations. We measured anthropometric variables (height and weight), metabolic parameters (blood pressure, fasting plasma glucose, triglyceride, and HDL cholesterol levels) and serum vitamin D levels. We analyzed the data using multivariate logistic regression models. Mean 25(OH)D levels were lower in children defined as obese or abdominally obese (P <0.001). When serum levels of 25(OH)D were divided into quartiles, BMI, waist circumference, and triglyceride levels were lower, and HDL cholesterol levels were higher, as vitamin D levels increased. Using children from the highest quartile of 25(OH)D levels as a referent, the adjusted ORs (95% CI) for obesity in those in the third, second, and lowest quartiles of 25(OH)D levels were 1.55 (1.01-2.40), 1.87 (1.22-2.85), and 2.59 (1.71-3.90), respectively (P for trend <0.001). For abdominal obesity the ORs (CI) were 2.08 (1.20-3.60), 2.32 (1.36-3.95), and 2.96 (1.75-5.00) (P for trend<0.001), and for metabolic syndrome they were 2.60 (1.08-6.30), 4.00 (1.73-9.26), and 4.25 (1.84-9.85), respectively (P for trend <0.05).
We found low vitamin D levels in Korean children to be associated with obesity and metabolic syndrome. Insufficient serum vitamin D levels in children may be a risk factor of obesity and metabolic syndrome.
关于血清维生素 D 水平与儿童心血管危险因素之间关系的证据有限。我们研究了血清维生素 D 水平（25-羟维生素 D [25(OH)D]）与韩国儿童肥胖和代谢综合征及其各组分之间的相关性。
我们招募了 1660 名 9 岁的韩国儿童（904 名男孩和 756 名女孩），他们在学校体检期间自愿参加了这项研究。我们测量了人体测量学变量（身高和体重）、代谢参数（血压、空腹血糖、甘油三酯和高密度脂蛋白胆固醇水平）和血清维生素 D 水平。我们使用多元逻辑回归模型分析了数据。肥胖或腹型肥胖儿童的平均 25(OH)D 水平较低（P<0.001）。当血清 25(OH)D 水平分为四组时，随着维生素 D 水平的升高，BMI、腰围和甘油三酯水平降低，而高密度脂蛋白胆固醇水平升高。以血清 25(OH)D 水平最高四分位数的儿童为参照，血清 25(OH)D 水平处于第三、第二和最低四分位数的儿童肥胖的调整比值比（95%可信区间）分别为 1.55（1.01-2.40）、1.87（1.22-2.85）和 2.59（1.71-3.90）（P<0.001）。对于腹型肥胖，比值比（CI）分别为 2.08（1.20-3.60）、2.32（1.36-3.95）和 2.96（1.75-5.00）（P<0.001），代谢综合征的比值比（CI）分别为 2.60（1.08-6.30）、4.00（1.73-9.26）和 4.25（1.84-9.85）（P<0.05）。
我们发现韩国儿童维生素 D 水平较低与肥胖和代谢综合征有关。儿童血清维生素 D 水平不足可能是肥胖和代谢综合征的一个危险因素。
