Institute of Collective Health, Federal University of Bahia, Rua Basílio da Gama, s/n, 40110-040, Salvador, Bahia, Brazil.
School of Nutrition, Universidade Federal da Bahia, 40110-150, Salvador, Brazil.
Rev Endocr Metab Disord. 2022 Oct;23(5):995-1010. doi: 10.1007/s11154-022-09736-7. Epub 2022 Jun 17.
Vitamin D deficiency is associated with an increase in the occurrence of cardiometabolic events, but the evidence of this relationship in adolescence is still limited. Thus, we analyzed the association between vitamin D deficiency and cardiometabolic risk factors in adolescents. Observational studies were searching in PubMed/Medline, Embase, Scopus, Web of Science, Science Direct, Lilacs, and Google Scholar database. Random effects models were used to summarize standardized mean differences for as a summary measure. The certainty of the evidence was verified using the Cochrane recommendations. A total of 7537 studies were identified, of which 32 were included in the systematic review and 24 in the meta-analysis.Vitamin D deficiency was associated with increased systolic pressure (SMD = 0.22; 95%CI = 0.10; 0.34), diastolic pressure (SMD = 0.23; 95%CI = 0.10; 0.35), glycemia (SMD = 0.13; 95%CI = 0.05; 0.12), and insulin (SMD = 0.50; 95%CI = 0.15; 0.84), an increase in the HOMA index (SMD = 0.48; 95%CI = 0.36; 0.60), high triglyceride values (SMD = 0.30; 95%CI = 0.11; 0.49), and reduced HDL concentrations (SMD= -0.25; 95%CI = -0.46; -0.04). No statistically significant association was observed for glycated hemoglobin, LDL cholesterol, and total cholesterol. Most of the studies presented low and moderate risks of bias, respectively. The certainty of the evidence was very low for all the outcomes analyzed. Vitamin D deficiency was associated with increased exposure to the factors linked to the occurrence of cardiometabolic diseases in adolescents. Systematic Review Registration: PROSPERO (record number 42,018,086,298).
维生素 D 缺乏与心脏代谢事件的发生增加有关，但这一关系在青少年中的证据仍然有限。因此，我们分析了青少年维生素 D 缺乏与心脏代谢危险因素之间的关系。在 PubMed/Medline、Embase、Scopus、Web of Science、Science Direct、Lilacs 和 Google Scholar 数据库中进行了观察性研究检索。使用随机效应模型汇总标准化均数差作为汇总指标。使用 Cochrane 推荐意见验证证据的确定性。共确定了 7537 项研究，其中 32 项被纳入系统评价，24 项被纳入荟萃分析。维生素 D 缺乏与收缩压（SMD=0.22；95%CI=0.10；0.34）、舒张压（SMD=0.23；95%CI=0.10；0.35）、血糖（SMD=0.13；95%CI=0.05；0.12）和胰岛素（SMD=0.50；95%CI=0.15；0.84）升高、HOMA 指数（SMD=0.48；95%CI=0.36；0.60）升高、甘油三酯值升高（SMD=0.30；95%CI=0.11；0.49）和高密度脂蛋白浓度降低（SMD=-0.25；95%CI=-0.46；-0.04）有关。糖化血红蛋白、LDL 胆固醇和总胆固醇没有观察到统计学上的显著相关性。大多数研究的偏倚风险分别为低和中度。所有分析结果的证据确定性均非常低。维生素 D 缺乏与青少年中与心脏代谢疾病发生相关的因素暴露增加有关。系统评价注册：PROSPERO（记录号 42,018,086,298）。
