Center for Data Analysis and Modeling (FDM), University of Freiburg, Breisacher Strasse 64, Freiberg, Germany.
Ultrasound Med Biol. 2012 Sep;38(9):1546-51. doi: 10.1016/j.ultrasmedbio.2012.05.003. Epub 2012 Jul 3.
Transcranial Doppler sonography allows for noninvasive assessment of dynamic cerebral autoregulation. A wider clinical use of this approach has been hampered by the need for continuous arterial blood pressure (ABP) measurements. We describe a new method of a pure Doppler signal based estimation of dynamic autoregulation using heart rate (HR) and cerebral blood flow velocity (CBFV) information. The phase between these two signals was assessed from 0.1 Hz oscillations induced by regular breathing. We compared this new approach with the standard method (phase between ABP and CBFV oscillations) in 93 patients with unilateral severe carotid artery obstruction. On a group level, the phase HR-CBFV differed significantly between ipsi- and contralateral sides (p = 0.024) and correlated significantly with the standard phase ABP-CBFV (r = 0.369, p < 0.001). The proposed method can, thus, detect impaired dynamic autoregulation in occlusive carotid artery disease using a single Doppler probe.
经颅多普勒超声允许对动态脑自动调节进行非侵入性评估。由于需要连续测量动脉血压 (ABP)，这种方法的广泛临床应用受到了阻碍。我们描述了一种新的方法，使用心率 (HR) 和脑血流速度 (CBFV) 信息，基于纯多普勒信号来估计动态自动调节。从由规律呼吸引起的 0.1 Hz 振荡中评估这两个信号之间的相位。我们在 93 例单侧严重颈动脉阻塞患者中比较了这种新方法与标准方法（ABP 和 CBFV 振荡之间的相位）。在组水平上，同侧和对侧 HR-CBFV 之间的相位差异具有统计学意义（p = 0.024），并且与标准的 ABP-CBFV 相位显著相关（r = 0.369，p < 0.001）。因此，该方法可以使用单个多普勒探头检测到闭塞性颈动脉疾病中的动态自动调节受损。
