Guité P, Lachapelle P
Department of Neurology and Neurosurgery, McGill University, Montreal, Canada.
Doc Ophthalmol. 1990 Sep;75(2):125-33. doi: 10.1007/BF00146548.
Previous reports have shown that an intravitreal injection of 2-amino-4-phosphonobutyric acid, a glutamate analogue that selectively blocks the photoreceptors' input to the on-bipolar cells, produces a rapid decrease in the amplitude of the electroretinographic b-wave. To our knowledge, the effect of this glutamate analogue has not been examined on the oscillatory potentials. We therefore conducted such a study. A needle electrode was inserted into the anterior chamber of the eyes of seven anesthetized and paralyzed rabbits to record simultaneously the electroretinogram and the oscillatory potentials. These responses were evoked by flashes of white light delivered in mesopic conditions. As expected, an injection of 2-amino-4-phosphonobutyric acid, produced a rapid decrease in the amplitude of the b-wave, while the a-wave was relatively spared. The amplitude of the oscillatory potentials also decreased rapidly. At maximal effect, the electroretinogram essentially consisted of a normal a-wave followed by small oscillations and no evidence of a b-wave. The 100-1000 Hz recording confirmed that the oscillations seen on the postinjection electroretinograms were remnants of the original oscillatory potentials.
先前的报告显示，玻璃体内注射2-氨基-4-膦酰丁酸（一种选择性阻断光感受器向on-双极细胞输入的谷氨酸类似物）会使视网膜电图b波的振幅迅速降低。据我们所知，尚未研究这种谷氨酸类似物对振荡电位的影响。因此，我们进行了这样一项研究。将针电极插入七只麻醉并瘫痪的兔子的眼前房，以同时记录视网膜电图和振荡电位。这些反应由中暗视觉条件下的白光闪光诱发。正如预期的那样，注射2-氨基-4-膦酰丁酸后，b波的振幅迅速降低，而a波相对未受影响。振荡电位的振幅也迅速降低。在最大效应时，视网膜电图基本上由正常的a波、随后的小振荡组成，且没有b波的迹象。100-1000Hz的记录证实，注射后视网膜电图上看到的振荡是原始振荡电位的残余。
