Wachtmeister L
Acta Ophthalmol (Copenh). 1981 Apr;59(2):247-58. doi: 10.1111/j.1755-3768.1981.tb02987.x.
The effects on the oscillatory potentials (OPs) of the ERG of some pharmacological agents, which antagonize the putative neurotransmitters glutamate aspartate and dopamine were tested. GDEE and alpha-aminoadipate, blocking agents of the excitatory amino acids glutamate and aspartate, respectively, decreased the amplitude of all the OPs. The amplitude of the b-wave was simultaneously reduced. Thus, no selective or differential sensitivity of the OPs was found, which suggests that glutamate- or aspartate-sensitive neuronal pathways do not seem to be directly involved in the generation of the OPs. Haloperidol, which antagonizes the effect of the inhibitory transmitter agent dopamine, differentially affected the OPs. The earlier OPs appeared more sensitive to low doses of the drug than the later ones. Such doses only slightly decreased the maximum amplitude of the b-wave and did not affect the a-wave. Thus, these findings indicate and support previous suggestions that the individual oscillatory peaks are likely to have different origins and that only inhibitory feed-back synapses give rise to the OPs.
测试了一些拮抗假定神经递质谷氨酸、天冬氨酸和多巴胺的药物制剂对视网膜电图振荡电位（OPs）的影响。分别作为兴奋性氨基酸谷氨酸和天冬氨酸阻断剂的甘氨酸二乙酯（GDEE）和α-氨基己二酸降低了所有OPs的振幅。b波的振幅同时降低。因此，未发现OPs有选择性或差异敏感性，这表明谷氨酸或天冬氨酸敏感的神经通路似乎未直接参与OPs的产生。拮抗抑制性递质多巴胺作用的氟哌啶醇对OPs有不同影响。较早出现的OPs比较晚出现的对低剂量药物更敏感。这样的剂量仅略微降低b波的最大振幅，且不影响a波。因此，这些发现表明并支持了先前的推测，即各个振荡峰可能有不同的起源，并且只有抑制性反馈突触产生OPs。
