Department of Mechanical Engineering, Chosun University, Gwangju, South Korea.
Bioprocess Biosyst Eng. 2013 Feb;36(2):205-14. doi: 10.1007/s00449-012-0776-3. Epub 2012 Jul 5.
In this work, we fabricated highly aligned electrospun poly(ε-caprolactone)(PCL)/collagen biocomposites, which were consisted of multi-layered structure. The aligned directions of the composites were controlled with two rotating collectors, and various weight fractions (1, 2, 3 wt%) of collagen were embedded between the mat of PCL microfibers to improve the mechanical property and biological activities of osteoblast-like cells (MG63). The PCL/collagen biocomposite showed nine times of increment in mechanical strength of random PCL/collagen composite. An increase in collagen content in the biocomposites displayed significant increase of mechanical properties, hydrophilic property, water-absorption ability, and even cell viability of osteoblast-like cells (MG63).
在这项工作中，我们制备了高度取向的电纺聚己内酯(PCL)/胶原蛋白生物复合材料，其具有多层结构。复合材料的取向方向通过两个旋转收集器进行控制，并且在 PCL 微纤维垫之间嵌入了不同重量分数(1、2、3wt%)的胶原蛋白，以提高成骨样细胞(MG63)的机械性能和生物活性。PCL/胶原蛋白生物复合材料的机械强度比随机 PCL/胶原蛋白复合材料提高了九倍。生物复合材料中胶原蛋白含量的增加显著提高了机械性能、亲水性、吸水性，甚至成骨样细胞(MG63)的细胞活力。
