MMWR Morb Mortal Wkly Rep. 2012 Jul 6;61(26):480-3.
The Unexplained Respiratory Disease Outbreak (URDO) working group is a multidisciplinary team composed of approximately 40 scientists from across CDC with expertise in infectious and noninfectious respiratory diseases. The URDO working group was formed in 2004 to streamline CDC response efforts to assist local, state, and international public health officials in investigations of unexplained respiratory disease outbreaks. This report summarizes URDO working group activities from March 2007 through September 2011. During that period, the URDO working group was notified of 57 investigations and facilitated consultations with subject matter experts (in all 57 investigations), laboratory testing at CDC (in 42 investigations), and on-site field investigation support (in eight investigations). Of these 57 investigations, 41 occurred domestically, and 16 occurred internationally. An etiology was identified in 29 (51%) investigations; among these, the most commonly implicated pathogens were noninfluenza respiratory viruses (41%), influenza viruses (17%), Mycoplasma pneumoniae (14%), and Bordetella pertussis (14%). Notification occurred a median of 33 days after illness onset in the first case, which might have limited the ability to collect early laboratory specimens or epidemiologic data. Reducing delays in sample collection, epidemiologic investigations, and consultation with the URDO working group might increase the ability to identify etiologies and lead to more rapid control of these unexplained respiratory disease outbreaks.
不明原因呼吸道疾病疫情（URDO）工作组是一个多学科团队，由美国疾病控制与预防中心（CDC）的大约 40 名具有传染病和非传染性呼吸道疾病专业知识的科学家组成。URDO 工作组成立于 2004 年，旨在简化 CDC 的应对措施，协助地方、州和国际公共卫生官员调查不明原因的呼吸道疾病疫情。本报告总结了 2007 年 3 月至 2011 年 9 月期间 URDO 工作组的活动。在此期间，URDO 工作组共收到 57 项调查通知，并协助进行了专题专家咨询（所有 57 项调查）、CDC 实验室检测（42 项调查）和现场调查支持（8 项调查）。在这 57 项调查中，有 41 项发生在国内，16 项发生在国际上。在 29 项（51%）调查中确定了病因；在这些调查中，最常见的病原体是非流感呼吸道病毒（41%）、流感病毒（17%）、肺炎支原体（14%）和百日咳博德特菌（14%）。首例病例发病后中位通知时间为 33 天，这可能限制了早期采集实验室标本或流行病学数据的能力。减少样本采集、流行病学调查和与 URDO 工作组咨询的延迟，可能会提高确定病因的能力，并有助于更迅速地控制这些不明原因的呼吸道疾病疫情。
