Laboratoire des Glucides CNRS FRE 3517, Institut de Chimie de Picardie, Université de Picardie Jules Verne, 33 Rue Saint-Leu, 80039 Amiens Cedex 1, France.
Chemistry. 2012 Aug 6;18(32):10021-8. doi: 10.1002/chem.201200887. Epub 2012 Jul 4.
The synthesis of four GlcNAc(β1→4)Glc disaccharides containing 2-O-acetyl and/or 6-sulfate groups was performed in high yields with total 1,2-trans stereoselectivity. These disaccharides were evaluated as candidates for insect chitinase inhibition and aphicidal activity. All the compounds prepared displayed physiological effects on M. persicae aphids; however, the inhibition of chitinases of different sources (bacteria, fungus, and aphid) followed different patterns according to subtle structural characteristics.
以高产率和总 1,2-反式立体选择性合成了四种含有 2-O-乙酰基和/或 6-硫酸盐基团的 GlcNAc(β1→4)Glc 二糖。这些二糖被评估为昆虫几丁质酶抑制剂和杀蚜虫活性的候选物。所有制备的化合物对烟粉虱均表现出生理效应；然而，根据细微的结构特征，不同来源（细菌、真菌和蚜虫）的几丁质酶的抑制遵循不同的模式。
