内毒素和纤维蛋白原降解产物（FDPS）对肝脏纤维蛋白原和白蛋白合成的不同影响：一种新型单核因子参与FDPS诱导的纤维蛋白原合成刺激的证据。

Differential effects of endotoxin and fibrinogen degradation products (FDPS) on liver synthesis of fibrinogen and albumin: evidence for the involvement of a novel monokine in the stimulation of fibrinogen synthesis induced by FDPS.

Moshage H J, Princen H M, van Pelt J, Roelofs H M, Nieuwenhuizen W, Yap S H

Department of Medicine, University Hospital of Nijmegen, The Netherlands.

Int J Biochem. 1990;22(12):1393-400. doi: 10.1016/0020-711x(90)90228-u.

Abstract

Administration of endotoxin or fibrinogen degradation products (FDPs) in rats increase fibrinogen synthesis comparable to that found during the acute phase response. 2. An increased fibrinogen synthesis is also found in co-cultures of hepatocytes with peripheral blood mononuclear cells upon administration of endotoxin or FDPs, but not in primary cultures of hepatocytes alone. 3. However, the increased synthesis of fibrinogen by FDPs is not accompanied by a decreased albumin synthesis, as in the case of stimulated fibrinogen synthesis induced by endotoxin in vivo and in co-cultures of hepatocytes with peripheral blood mononuclear cells, or induced by monocytic products in vivo and in primary cultures of hepatocytes alone. 4. Since IL-1 and/or IL-6 could not be accounted for the stimulation of fibrinogen synthesis without a decreased albumin synthesis, a novel monokine produced by mononuclear cells upon FDP administration might be involved.

摘要

给大鼠注射内毒素或纤维蛋白原降解产物（FDPs）可增加纤维蛋白原的合成，其水平与急性期反应期间相当。2. 在内毒素或FDPs给药后，肝细胞与外周血单核细胞的共培养物中也发现纤维蛋白原合成增加，但单独的肝细胞原代培养物中未出现这种情况。3. 然而，FDPs引起的纤维蛋白原合成增加并不伴随着白蛋白合成减少，而内毒素在体内及肝细胞与外周血单核细胞共培养时引起的纤维蛋白原合成增加，以及单核细胞产物在体内及单独的肝细胞原代培养时引起的纤维蛋白原合成增加，均伴随着白蛋白合成减少。4. 由于白细胞介素-1和/或白细胞介素-6无法解释在白蛋白合成未减少的情况下纤维蛋白原合成的刺激现象，因此可能涉及单核细胞在FDP给药后产生的一种新型单核因子。