Department of Natural Products Chemistry, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China.
Cell Prolif. 2012 Oct;45(5):466-76. doi: 10.1111/j.1365-2184.2012.00833.x. Epub 2012 Jul 6.
Natural compounds derived from plant sources are well characterized as possessing a wide variety of remarkable anti-tumour properties, for example modulating programmed cell death, primarily referring to apoptosis, and autophagy. Distinct from apoptosis, autophagy (an evolutionarily conserved, multi-step lysosomal degradation process in which a cell destroys long-lived proteins and damaged organelles) may play crucial regulatory roles in many pathological processes, most notably in cancer. In this review, we focus on highlighting several representative plant natural compounds such as curcumin, resveratrol, paclitaxel, oridonin, quercetin and plant lectin - that may lead to cancer cell death - for regulation of some core autophagic pathways, involved in Ras-Raf signalling, Beclin-1 interactome, BCR-ABL, PI3KCI/Akt/mTOR, FOXO1 signalling and p53. Taken together, these findings would provide a new perspective for exploiting more plant natural compounds as potential novel anti-tumour drugs, by targeting the pathways of autophagy, for future cancer therapeutics.
植物来源的天然化合物具有广泛的抗肿瘤特性，例如调节程序性细胞死亡，主要是指细胞凋亡和自噬。与细胞凋亡不同，自噬（一种进化上保守的、多步骤的溶酶体降解过程，其中细胞破坏长寿蛋白和受损的细胞器）在许多病理过程中可能发挥关键的调节作用，特别是在癌症中。在这篇综述中，我们重点强调了几种代表性的植物天然化合物，如姜黄素、白藜芦醇、紫杉醇、冬凌草甲素、槲皮素和植物凝集素，它们可能导致癌细胞死亡，调节 Ras-Raf 信号、Beclin-1 相互作用体、BCR-ABL、PI3KCI/Akt/mTOR、FOXO1 信号和 p53 等核心自噬途径。总之，这些发现为开发更多的植物天然化合物作为潜在的新型抗肿瘤药物提供了新的视角，通过靶向自噬途径，为未来的癌症治疗提供了新的策略。
