Neuroscience Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Medical Toxicology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Curr Drug Targets. 2020;21(12):1237-1249. doi: 10.2174/1389450121666200504072635.
Nowadays, natural compounds of plant origin with anticancer effects have gained more attention because of their clinical safety and broad efficacy profiles. Autophagy is a multistep lysosomal degradation pathway that may have a unique potential for clinical benefit in the setting of cancer treatment. To retrieve articles related to the study, the databases of Google Scholar, Web of sciences, Medline and Scopus, using the following keywords: Autophagic pathways; herbal medicine, oncogenic autophagic pathways, tumor-suppressive autophagic pathways, and cancer were searched. Although natural plant compounds such as resveratrol, curcumin, oridonin, gossypol, and paclitaxel have proven anticancer potential via autophagic signaling pathways, there is still a great need to find new natural compounds and investigate the underlying mechanisms, to facilitate their clinical use as potential anticancer agents through autophagic induction.
如今，具有抗癌作用的植物源性天然化合物因其临床安全性和广泛的疗效而受到更多关注。自噬是一种多步骤的溶酶体降解途径，在癌症治疗中可能具有独特的临床获益潜力。为了检索与研究相关的文章，使用以下关键字在 Google Scholar、Web of sciences、Medline 和 Scopus 数据库中进行搜索：自噬途径；草药、致癌自噬途径、肿瘤抑制自噬途径和癌症。虽然天然植物化合物，如白藜芦醇、姜黄素、冬凌草甲素、棉酚和紫杉醇，已通过自噬信号通路证明具有抗癌潜力，但仍迫切需要寻找新的天然化合物并研究其潜在机制，以促进其通过自噬诱导作为潜在抗癌药物的临床应用。
