斯里兰卡一些药用植物的降血糖活性。

Hypoglycaemic activity of some medicinal plants in Sri-Lanka.

Fernando M R, Thabrew M I, Karunanayake E H

Department of Biochemistry, Faculty of Medicine, University of Ruhuna, Sri-Lanka.

Gen Pharmacol. 1990;21(5):779-82. doi: 10.1016/0306-3623(90)91033-n.

Abstract

Investigations were carried out to determine whether aqueous extracts of Osbeckia octandra, Artocarpus heterophyllus and Bambusa vulgaris truly possess oral hypoglycaemic activity. 2. All three plant extracts significantly lowered the fasting blood glucose level and markedly improved glucose tolerance in Sprague-Dawley rats. 3. A maximum hypoglycaemic activity was observed at +3 hr with O. octandra and B. vulgaris; with A. heterophyllus a maximum effect was not observed even at +5 hr. 4. The hypoglycaemic activity of O. octandra was comparable with that of tolbutamide while that of A. heterophyllus or B. vulgaris was better than that of tolbutamide. 5. The magnitude of the hypoglycaemic effects varied with the dosage used and the time of storage (except with A. heterophyllus, whose activity did not change with storage even up to 3 days).

摘要

开展了多项研究以确定野牡丹、菠萝蜜和青皮竹的水提取物是否真的具有口服降血糖活性。2. 所有这三种植物提取物均能显著降低斯普拉格-道利大鼠的空腹血糖水平，并明显改善其葡萄糖耐量。3. 野牡丹和青皮竹在+3小时时观察到最大降血糖活性；而菠萝蜜即使在+5小时时也未观察到最大效果。4. 野牡丹的降血糖活性与甲苯磺丁脲相当，而菠萝蜜或青皮竹的降血糖活性优于甲苯磺丁脲。5. 降血糖作用的程度随所用剂量和储存时间而变化（菠萝蜜除外，其活性即使储存3天也不会改变）。