Université Paris Descartes, [corrected] Hôpital Saint Vincent de Paul/Cochin, Bâtiment [corrected] Petit, 82 Avenue Denfert-Rochereau 75014, Paris, France.
Cell Mol Life Sci. 2013 Jan;70(2):239-55. doi: 10.1007/s00018-012-1042-1. Epub 2012 Jul 6.
Type 1 diabetes is an autoimmune disease characterized by the destruction of insulin-producing pancreatic β-cells. Even though extensive scientific research has yielded important insights into the immune mechanisms involved in pancreatic β-cell destruction, little is known about the events that trigger the autoimmune process. Recent epidemiological and experimental data suggest that environmental factors are involved in this process. In this review, we discuss the role of viruses as an environmental factor on the development of type 1 diabetes, and the immune mechanisms by which they can trigger or protect against this pathology.
1 型糖尿病是一种自身免疫性疾病，其特征是产生胰岛素的胰腺β细胞遭到破坏。尽管广泛的科学研究已经深入了解了涉及胰腺β细胞破坏的免疫机制，但对于引发自身免疫过程的事件知之甚少。最近的流行病学和实验数据表明，环境因素在这一过程中起作用。在这篇综述中，我们讨论了病毒作为环境因素在 1 型糖尿病发展中的作用，以及它们引发或预防这种病理的免疫机制。
