经口给予大鼠FD&C黄色5号的致畸潜力研究。

Study of the teratogenic potential of FD & C Yellow No. 5 when given by gavage to rats.

作者信息

Collins T F, Black T N, Brown L H, Bulhack P

机构信息

Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204.

出版信息

Food Chem Toxicol. 1990 Dec;28(12):821-7. doi: 10.1016/0278-6915(90)90055-r.

DOI:10.1016/0278-6915(90)90055-r

PMID:2276704

Abstract

FD & C Yellow No. 5 (tartrazine) was given to Osborne-Mendel rats by gavage at dose levels of 0, 60, 100, 200, 400, 600 or 1000 mg/kg body weight/day on days 0-19 of gestation. No maternal or developmental toxicity was observed when the rats were killed on day 20. The mean daily food consumption for the entire period of gestation was significantly greater in the females given 1000 mg/kg body weight/day than in the controls, but maternal body-weight gain was not affected. No dose-related effects were observed in implantations, foetal viability or external foetal development. Foetal skeletal and visceral development was similar among foetuses from all groups. At the doses given, FD & C Yellow No. 5 was neither toxic nor teratogenic.

摘要

在妊娠第0至19天，通过灌胃法给奥斯本-孟德尔大鼠投喂不同剂量的FD&C 5号黄（柠檬黄），剂量水平分别为0、60、100、200、400、600或1000毫克/千克体重/天。在第20天处死大鼠时，未观察到母体毒性或发育毒性。给予1000毫克/千克体重/天的雌性大鼠在整个妊娠期的平均每日食物消耗量显著高于对照组，但母体体重增加未受影响。在着床、胎儿活力或胎儿外部发育方面未观察到剂量相关效应。所有组胎儿的骨骼和内脏发育相似。在所给剂量下，FD&C 5号黄既无毒性也无致畸性。