阿拉伯树胶致畸潜力的研究。

Study of the teratogenic potential of gum arabic.

作者信息

Collins T F, Welsh J J, Black T N, Graham S L, Brown L H

机构信息

Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204.

出版信息

Food Chem Toxicol. 1987 Nov;25(11):815-21. doi: 10.1016/0278-6915(87)90259-6.

DOI:10.1016/0278-6915(87)90259-6

PMID:3692387

Abstract

Gum arabic in the diet at 0, 1, 2, 4, 7.5 or 15% was available ad lib. to male and female Osborne-Mendel rats during premating and mating and throughout gestation. During gestation, the treated females consumed from 683 mg gum/kg body weight/day in the 1% group to 10,647 mg gum/kg/day in the 15% group. The animals were killed on gestation day 20. There were no dose-related changes in maternal findings, number of foetuses, foetal viability or external, visceral or skeletal variations. No terata were seen.

摘要

在交配前期、交配期以及整个妊娠期，向雄性和雌性奥斯本-孟德尔大鼠随意提供含0%、1%、2%、4%、7.5%或15%阿拉伯胶的饮食。在妊娠期，接受处理的雌性大鼠的阿拉伯胶摄入量从1%组的683毫克/千克体重/天到15%组的10,647毫克/千克体重/天不等。在妊娠第20天处死动物。母体检查结果、胎儿数量、胎儿活力或外部、内脏或骨骼变异方面均未出现与剂量相关的变化。未观察到畸形。