Landgraf R, Nusser J, Müller-Felber W, Wagner S, Scheider A, Meyer-Schwickerath E, Illner W D, Abendroth D, Land W
Medizinische Klinik Klinikum Innenstadt, Universität München.
Fortschr Med. 1990 Dec 10;108(35):668-71, 677.
Successful pancreas transplantation can result in the longterm normalization of glucose metabolism. Since most pancreas recipients already have severe diabetic complications, and the observation period after transplantation is rather short, an assessment of the effect of complete glucose normalization on these diabetic changes is problematic. It has, however, been shown that the development of diabetic nephropathy can be prevented, peripheral microcirculation improved, and autonomic and peripheral neuropathy and retinopathy stabilized. These positive effects are, possibly, in part due to the elimination of uremia, since most patients receive both a pancreas and a kidney. The aim must be to perform pancreas transplantation in an early stage of diabetes, even though remarkable improvements have also been reported in terminal stages of the disease, and the quality of life of these patients has been significantly improved.
成功的胰腺移植可使糖代谢长期恢复正常。由于大多数胰腺移植受者已经患有严重的糖尿病并发症，且移植后的观察期相当短，因此评估完全血糖正常化对这些糖尿病变化的影响存在问题。然而，已经表明糖尿病肾病的发展可以得到预防，外周微循环得到改善，自主神经和周围神经病变以及视网膜病变得以稳定。这些积极作用可能部分归因于尿毒症的消除，因为大多数患者同时接受胰腺和肾脏移植。目标必须是在糖尿病的早期阶段进行胰腺移植，尽管在疾病晚期也有显著改善的报道，并且这些患者的生活质量已得到显著提高。
