二尖瓣受累作为心脏淀粉样变性的主要特征。
Mitral valve involvement as a predominant feature of cardiac amyloidosis.
作者信息
Viswanathan Girish, Williams James, Slinn Simon, Campbell Philip
机构信息
Institute of Cellular Medicine, Newcastle upon Tyne, UK.
出版信息
BMJ Case Rep. 2010 Oct 10;2010:bcr0820080821. doi: 10.1136/bcr.08.2008.0821.
Abstract
Cardiac involvement in systemic amyloidosis carries poor prognosis with a median survival of 5 months.(1) The authors report an unusual presentation of cardiac amyloidosis in the form of predominant mitral regurgitation. The patient responded very well to medical therapy with subsequent improvement of mitral valve dysfunction. The authors would like to highlight this multisystem involvement and the presence of a complex overlap of systemic features.
摘要
系统性淀粉样变性累及心脏时预后较差，中位生存期为5个月。（1）作者报告了一例以重度二尖瓣反流为主要表现形式的罕见心脏淀粉样变性病例。该患者对药物治疗反应良好，二尖瓣功能障碍随后得到改善。作者希望强调这种多系统受累以及全身特征复杂重叠的情况。
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Blood. 2007 Jan 15;109(2):457-64. doi: 10.1182/blood-2006-07-035352. Epub 2006 Sep 21.
3
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