Kaaber S
Royal Dental College, Aarhus, Denmark.
Int Dent J. 1990 Dec;40(6):359-65.
The increase in new clinical materials with questionable biological properties and the corresponding increase in awareness in patients to health hazards from dental materials are two important problems of modern clinical dentistry. Based upon evidence from clinical research the hypersensitivity problems related to the use of silver amalgam and acrylic denture base materials are reviewed to define possible risk groups among dental patients. In silver amalgam therapy the main risk group is patients with contact lesions in the oral mucosa adjacent to the restorations, as this group exhibits a high frequency of skin sensitivity to mercury and other base materials in dental amalgam. Among denture wearers a corresponding risk group has been observed among patients with previous allergic diseases and burning mouth syndrome. In these cases a high incidence of skin sensitivity reactions to denture allergens has been observed, usually to methylmethacrylate monomer and formaldehyde. Some possible pathogenic mechanisms leading to a contact allergy of the oral mucosa in these patient groups are discussed.
具有可疑生物学特性的新型临床材料的增加以及患者对牙科材料健康危害认识的相应提高是现代临床牙科的两个重要问题。基于临床研究证据，对与使用银汞合金和丙烯酸义齿基托材料相关的超敏反应问题进行了综述，以确定牙科患者中可能的风险群体。在银汞合金治疗中，主要风险群体是修复体邻近口腔黏膜有接触性病变的患者，因为该群体对汞和牙科汞合金中的其他基础材料表现出较高的皮肤敏感性。在假牙佩戴者中，在患有既往过敏性疾病和灼口综合征的患者中观察到了相应的风险群体。在这些病例中，观察到对假牙过敏原的皮肤敏感反应发生率很高，通常是对甲基丙烯酸甲酯单体和甲醛。讨论了导致这些患者群体口腔黏膜接触性过敏的一些可能致病机制。
