Srivastava R, Srivastava N, Misra U K
Department of Biochemistry, Vallabhbhai Patel Chest Institute, University of Delhi, India.
Int J Vitam Nutr Res. 1990;60(3):236-9.
Effect of ethanol, cholesterol and vitamin A either alone or in combination has been studied on cyt P450 and phospholipid methylation in hepatic microsomes of rats. Ethanol increased cyt P450 activity and decreased phospholipid methylation. Cholesterol effects were opposite to ethanol. Combination of cholesterol and ethanol decreased cyt P450 activity and increased phospholipid methylation. Vitamin A, which alone did not affect cyt P450 activity and phospholipid methylation behaved like cholesterol when given along with ethanol.
已经研究了乙醇、胆固醇和维生素A单独或联合使用对大鼠肝微粒体中细胞色素P450和磷脂甲基化的影响。乙醇增加了细胞色素P450的活性并降低了磷脂甲基化。胆固醇的作用与乙醇相反。胆固醇和乙醇联合使用降低了细胞色素P450的活性并增加了磷脂甲基化。单独使用时不影响细胞色素P450活性和磷脂甲基化的维生素A，与乙醇一起使用时表现得与胆固醇相似。
