Conte A, Palmieri L, Ronca G, Giovannini L, Bertelli A
Institute of Biological Chemistry, School of Medicine, University of Pisa, Italy.
Int J Tissue React. 1990;12(3):197-201.
Exogenous L-carnitine and coenzyme Q are used to protect the heart against anthracycline damage and to enhance energy metabolism in the heart and in the muscle. Though their metabolic function is well known and their effects on anthracycline damage have been largely studied, their combined action has not been investigated. Therefore we have used partially CoQ-depleted bovine mitochondria to evaluate the synergic action of CoQ and carnitine on palmitoylCoA oxidation, as an experimental model in which either CoQ or L-carnitine may be the limiting factor in the oxidation of activated fatty acids. The protective effect exerted by the combined use of L-carnitine and CoQ against damage by the anthracycline derivative doxorubicin has been compared to the protection exerted by each compound alone. The effect was evaluated by assessing oxygen consumption and 14C-leucine incorporation in rat heart slices. The results obtained suggest that the administration of an association of L-carnitine and CoQ exerts a stronger protection against anthracycline damage and induces a greater utilization of fatty acids as compared to the effects of each compound alone.
外源性左旋肉碱和辅酶Q被用于保护心脏免受蒽环类药物损害，并增强心脏和肌肉中的能量代谢。尽管它们的代谢功能已为人所知，且对蒽环类药物损害的影响也已得到大量研究，但它们的联合作用尚未得到研究。因此，我们使用部分辅酶Q耗尽的牛线粒体来评估辅酶Q和肉碱对棕榈酰辅酶A氧化的协同作用，作为一种实验模型，其中辅酶Q或左旋肉碱可能是活化脂肪酸氧化的限制因素。将左旋肉碱和辅酶Q联合使用对蒽环类衍生物阿霉素损害的保护作用与每种化合物单独使用时的保护作用进行了比较。通过评估大鼠心脏切片中的氧气消耗和14C-亮氨酸掺入来评估这种作用。所得结果表明，与单独使用每种化合物的效果相比，给予左旋肉碱和辅酶Q的组合对蒽环类药物损害具有更强的保护作用，并能诱导更多地利用脂肪酸。
