在兔肝微粒体中，乙二胺四乙酸（EDTA）在亚铁离子存在的情况下增强了NADPH依赖性脂质过氧化活性。
Enhancement of NADPH-dependent lipid peroxidation activity by ethylene-diamineteraacetic acid (EDTA) in the presence of ferrous ion in rabbit liver microsomes.
作者信息
Kitada M, Kamataki T, Kitagawa H
出版信息
Jpn J Pharmacol. 1977 Oct;27(5):653-7. doi: 10.1254/jjp.27.653.
The addition of EDTA to the incubation mixture containing rabbit liver microsomes and ferrous ion resulted in 2-fold increase of lipid peroxidation activity. Such an enhancement was not observed in rat liver microsomes. The maximum lipid peroxidation activity seen in rabbit microsomes in the presence of EDTA and ferrous ion was about 80% that seen in rat liver microsomes. From these results, it is likely that low lipid peroxidation activity in rabbit liver microsomes may account for the insufficiency of an EDTA-LIKE FACTORS(S) IN RABBIT LIVER MICROSOMES.
在含有兔肝微粒体和亚铁离子的孵育混合物中添加乙二胺四乙酸（EDTA），导致脂质过氧化活性增加了两倍。在大鼠肝微粒体中未观察到这种增强现象。在存在EDTA和亚铁离子的情况下，兔微粒体中所见的最大脂质过氧化活性约为大鼠肝微粒体中所见活性的80%。从这些结果来看，兔肝微粒体中脂质过氧化活性较低可能是兔肝微粒体中类似EDTA因子不足的原因。
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