亚铁离子-乙二胺四乙酸刺激的磷脂过氧化。一种从依赖烷氧基自由基引发转变为依赖羟基自由基引发的反应。
Ferrous ion-EDTA-stimulated phospholipid peroxidation. A reaction changing from alkoxyl-radical- to hydroxyl-radical-dependent initiation.
作者信息
Gutteridge J M
出版信息
Biochem J. 1984 Dec 15;224(3):697-701. doi: 10.1042/bj2240697.
Abstract
The stimulatory effect of ferrous salts on the peroxidation of phospholipids can be enhanced by EDTA when the concentration of Fe2+ in the reaction is greater than that of EDTA. Hydroxyl-radical scavengers do not inhibit peroxidation until the concentrations of Fe2+ and EDTA in the reaction are equal. Lipid peroxidation is then substantially initiated by hydroxyl radicals derived from a Fenton-type reaction requiring hydrogen peroxide. Superoxide radicals appear to play some role in the formation of initiating species.
摘要
当反应中Fe2+的浓度大于EDTA的浓度时，EDTA可增强亚铁盐对磷脂过氧化的刺激作用。在反应中Fe2+和EDTA的浓度相等之前，羟基自由基清除剂不会抑制过氧化反应。然后，脂质过氧化主要由源自需要过氧化氢的芬顿型反应的羟基自由基引发。超氧自由基似乎在引发物种的形成中起一定作用。
相似文献
1
Ferrous ion-EDTA-stimulated phospholipid peroxidation. A reaction changing from alkoxyl-radical- to hydroxyl-radical-dependent initiation.亚铁离子-乙二胺四乙酸刺激的磷脂过氧化。一种从依赖烷氧基自由基引发转变为依赖羟基自由基引发的反应。
Biochem J. 1984 Dec 15;224(3):697-701. doi: 10.1042/bj2240697.
2
The requirement for ferric in the initiation of lipid peroxidation by chelated ferrous iron.螯合亚铁引发脂质过氧化过程中对三价铁的需求。
Biochem Biophys Res Commun. 1983 Mar 29;111(3):777-84. doi: 10.1016/0006-291x(83)91366-9.
3
Lipid peroxidation initiated by superoxide-dependent hydroxyl radicals using complexed iron and hydrogen peroxide.超氧化物依赖性羟基自由基利用络合铁和过氧化氢引发脂质过氧化。
FEBS Lett. 1984 Jul 9;172(2):245-9. doi: 10.1016/0014-5793(84)81134-5.
4
Importance of Fe2+-ADP and the relative unimportance of OH in the mechanism of mitomycin C-induced lipid peroxidation.Fe2+-ADP在丝裂霉素C诱导的脂质过氧化机制中的重要性及OH的相对不重要性。
Biochim Biophys Acta. 1984 Dec 6;796(3):285-93.
5
Mechanisms of lipid peroxidation dependent upon cytochrome P-450 LM2.依赖细胞色素P-450 LM2的脂质过氧化机制。
Eur J Biochem. 1986 Jul 1;158(1):195-201. doi: 10.1111/j.1432-1033.1986.tb09738.x.
6
The requirement for iron (III) in the initiation of lipid peroxidation by iron (II) and hydrogen peroxide.铁（II）和过氧化氢引发脂质过氧化过程中对铁（III）的需求。
J Biol Chem. 1987 Jan 25;262(3):1098-104.
7
Aluminium salts accelerate peroxidation of membrane lipids stimulated by iron salts.铝盐会加速铁盐刺激引起的膜脂质过氧化。
Biochim Biophys Acta. 1985 Jul 31;835(3):441-7. doi: 10.1016/0005-2760(85)90113-4.
8
The involvement of iron in lipid peroxidation. Importance of ferric to ferrous ratios in initiation.铁在脂质过氧化中的作用。三价铁与二价铁比例在引发过程中的重要性。
J Biol Chem. 1986 Aug 5;261(22):10282-9.
9
Initiation of lipid peroxidation in biological systems.生物系统中脂质过氧化的引发
Crit Rev Food Sci Nutr. 1987;25(4):317-64. doi: 10.1080/10408398709527457.
10
The role of Fe3+ on Fe2+-dependent lipid peroxidation in phospholipid liposomes.Fe3+对磷脂脂质体中Fe2+依赖性脂质过氧化的作用。
Chem Pharm Bull (Tokyo). 2002 Feb;50(2):203-7. doi: 10.1248/cpb.50.203.
引用本文的文献
1
Duration of the Flaxseed Supplementation Affects Antioxidant Defence Mechanisms and the Oxidative Stress of Fattening Pigs.亚麻籽补充剂的持续时间影响育肥猪的抗氧化防御机制和氧化应激。
Vet Sci. 2023 Sep 21;10(9):586. doi: 10.3390/vetsci10090586.
2
Sunitinib and Pterostilbene Combination Treatment Exerts Antitumor Effects in Gastric Cancer via Suppression of PDZD8.西地尼布与白藜芦醇联合治疗通过抑制 PDZD8 发挥胃癌的抗肿瘤作用。
Int J Mol Sci. 2022 Apr 4;23(7):4002. doi: 10.3390/ijms23074002.
3
Toxicity of oxalic acid and impact on some antioxidant enzymes on in vitro-reared honeybee larvae.草酸的毒性及其对体外饲养的蜜蜂幼虫某些抗氧化酶的影响。
Environ Sci Pollut Res Int. 2019 Jul;26(19):19763-19769. doi: 10.1007/s11356-019-05247-2. Epub 2019 May 14.
4
Formetanate toxicity and changes in antioxidant enzyme system of Apis mellifera larvae.杀螨脒对意大利蜜蜂幼虫的毒性及抗氧化酶系统的变化
Environ Sci Pollut Res Int. 2017 Jun;24(16):14060-14070. doi: 10.1007/s11356-017-8966-9. Epub 2017 Apr 13.
5
Heavy Metals and Human Health: Mechanistic Insight into Toxicity and Counter Defense System of Antioxidants.重金属与人类健康：抗氧化剂毒性及防御机制的深入洞察
Int J Mol Sci. 2015 Dec 10;16(12):29592-630. doi: 10.3390/ijms161226183.
6
Changes in dry state hemoglobin over time do not increase the potential for oxidative DNA damage in dried blood.干燥状态下血红蛋白随时间的变化不会增加干血中氧化性DNA损伤的可能性。
PLoS One. 2009;4(4):e5110. doi: 10.1371/journal.pone.0005110. Epub 2009 Apr 8.
7
8
Role of Fe(III) in Fe(II)citrate-mediated peroxidation of mitochondrial membrane lipids.铁（III）在柠檬酸亚铁介导的线粒体膜脂过氧化中的作用。
Mol Cell Biochem. 1999 Jun;196(1-2):163-8.
9
Inhibition of Fe(II) catalyzed linoleic acid oxidation and DNA damage by phosvitin.磷蛋白对亚铁催化的亚油酸氧化和DNA损伤的抑制作用。
Mol Cell Biochem. 1997 Dec;177(1-2):47-51. doi: 10.1023/a:1006865129856.
10
An esterification protocol for cis-parinaric acid-determined lipid peroxidation in immune cells.一种用于测定免疫细胞中顺式十八碳四烯酸脂质过氧化的酯化方案。
Lipids. 1997 Feb;32(2):219-26. doi: 10.1007/s11745-997-0028-x.
本文引用的文献
1
MECHANISMS OF LIPID PEROXIDE FORMATION IN TISSUES. ROLE OF METALS AND HAEMATIN PROTEINS IN THE CATALYSIS OF THE OXIDATION UNSATURATED FATTY ACIDS.组织中脂质过氧化物形成的机制。金属和血红素蛋白在催化不饱和脂肪酸氧化中的作用。
Biochim Biophys Acta. 1965 Apr 5;98:238-51. doi: 10.1016/0005-2760(65)90118-9.
2
Detection by fluorescence of peroxides and carbonyls in samples of arachidonic acid.通过荧光检测花生四烯酸样品中的过氧化物和羰基化合物。
Br J Pharmacol. 1982 Jul;76(3):459-61. doi: 10.1111/j.1476-5381.1982.tb09240.x.
3
Stimulation of microsomal lipid peroxidation by iron and cysteine. Characterization and the role of free radicals.铁和半胱氨酸对微粒体脂质过氧化的刺激作用。自由基的特性及作用
Biochem J. 1983 Jun 15;212(3):549-54. doi: 10.1042/bj2120549.
4
The multiple effects of ethylenediaminetetraacetate in several model lipid peroxidation systems.乙二胺四乙酸在几种模型脂质过氧化系统中的多重效应。
Arch Biochem Biophys. 1982 Oct 15;218(2):450-8. doi: 10.1016/0003-9861(82)90367-8.
5
6
Superoxide-dependent lipid peroxidation. Problems with the use of catalase as a specific probe for fenton-derived hydroxyl radicals.超氧化物依赖性脂质过氧化。将过氧化氢酶用作铁离子诱导产生的羟基自由基特异性探针的问题。
Biochem Biophys Res Commun. 1983 Dec 28;117(3):901-7. doi: 10.1016/0006-291x(83)91681-9.
7
The role of superoxide and hydroxyl radicals in phospholipid peroxidation catalysed by iron salts.超氧化物和羟基自由基在铁盐催化的磷脂过氧化反应中的作用。
FEBS Lett. 1982 Dec 27;150(2):454-8. doi: 10.1016/0014-5793(82)80788-6.
8
Formation of thiobarbituric-acid-reactive substance from deoxyribose in the presence of iron salts: the role of superoxide and hydroxyl radicals.在铁盐存在下由脱氧核糖形成硫代巴比妥酸反应性物质：超氧自由基和羟自由基的作用
FEBS Lett. 1981 Jun 15;128(2):347-52. doi: 10.1016/0014-5793(81)80114-7.
9
Lipid peroxide formation in microsomes. The role of non-haem iron.微粒体中脂质过氧化物的形成。非血红素铁的作用。
Biochem J. 1969 Jun;113(2):325-32. doi: 10.1042/bj1130325.
10
The measurement of malondialdehyde in peroxidised ox-brain phospholipid liposomes.过氧化牛脑磷脂脂质体中丙二醛的测定
Anal Biochem. 1977 Sep;82(1):76-82. doi: 10.1016/0003-2697(77)90136-1.
Zotero 插件