Laboratory of Electrochemistry, Faculty of Chemistry, University of Warsaw, Pasteura 1, Warsaw 02-093, Poland.
Bioelectrochemistry. 2013 Oct;93:2-14. doi: 10.1016/j.bioelechem.2012.06.001. Epub 2012 Jun 19.
In the need of development of versatile and flexible platforms for sensing, nanostructured particles are one of the systems of choice. Additionally, the state-of-the-art, controlled surface modifications of these structures offer broad possibilities of using such systems for diagnostics and therapy, often referred to as thera(g)nostics. In this brief review we will focus on the synthesis and surface modifications of solid-core magnetic nanostructures and polymeric capsules containing nanoferrites modified with anti-cancer drug--doxorubicin, designed for magnetic field-driven drug delivery for cancer therapy. We will also outline some problems related to the usage of such structures. The encapsulation and distribution of magnetic iron oxide nanoparticles modified with doxorubicin will be demonstrated in the polypyrrole spherical microvessels.
在对多功能和灵活平台的发展需求下，纳米结构颗粒是首选系统之一。此外，这些结构的最先进的、受控制的表面修饰为将此类系统用于诊断和治疗提供了广泛的可能性，通常被称为治疗诊断学。在这篇简要综述中，我们将重点介绍含有纳米铁氧体的固芯磁性纳米结构和聚合物胶囊的合成和表面修饰，这些纳米铁氧体用抗癌药物阿霉素修饰，旨在用于磁场驱动的癌症治疗药物输送。我们还将概述与使用此类结构相关的一些问题。将用阿霉素修饰的磁性氧化铁纳米颗粒包封并分布在聚吡咯球形微管中。
