Department of Cardiology, City Hospital, Birmingham B18 7QH, UK.
Thromb Res. 2012 Oct;130(4):607-11. doi: 10.1016/j.thromres.2012.05.033. Epub 2012 Jul 6.
Several inflammatory markers have been shown to be independent predictors for both the development of clinically significant atherosclerosis and for adverse outcome in patients with symptomatic coronary artery disease (CAD). We investigated the prognostic role of eosinophil count in low to intermediate risk patients with CAD.
We studied 909 patients admitted for elective or urgent percutaneous coronary intervention (PCI) from April 2002 to December 2004, and measured pre-procedural total and differential white blood cell (WBC) counts. Inter-tertile WBC differences in short (6months) and long term (up to 74months) mortality were analysed after adjusting for differences in baseline characteristics.
Over a median period of 54months (inter-quartile range 47-65), a total of 138 deaths (15.2%) occurred, of which 24 were in the first 6months of follow-up. Cox regression analysis showed that high pre-procedural eosinophil count (top tertile) was associated with improved outcome within the first 6months (OR=0.23 [0.06-0.84]; p=0.03) but after this period there was an increased risk of mortality (OR=2.21, [1.26-3.88]; p=0.006).
Eosinophil count is a novel biomarker for risk stratification of CAD patients, which was associated initially with reduced mortality, but after 6months with increased mortality.
多项炎症标志物已被证明是有症状的冠心病（CAD）患者发生临床显著动脉粥样硬化和不良预后的独立预测因子。我们研究了嗜酸性粒细胞计数在 CAD 低至中危患者中的预后作用。
我们研究了 2002 年 4 月至 2004 年 12 月期间因选择性或紧急经皮冠状动脉介入治疗（PCI）入院的 909 例患者，并测量了术前总白细胞计数和白细胞分类计数。在调整基线特征差异后，分析了短期（6 个月）和长期（长达 74 个月）死亡率的白细胞差异。
在中位数为 54 个月（四分位距 47-65）的期间内，共有 138 例死亡（15.2%），其中 24 例发生在随访的前 6 个月内。Cox 回归分析显示，高术前嗜酸性粒细胞计数（最高三分位）与前 6 个月内的改善结果相关（OR=0.23 [0.06-0.84]；p=0.03），但在此期间，死亡率的风险增加（OR=2.21，[1.26-3.88]；p=0.006）。
嗜酸性粒细胞计数是 CAD 患者风险分层的一种新的生物标志物，最初与死亡率降低相关，但 6 个月后与死亡率增加相关。
