Bennett W M
Department of Medicine, Oregon Health Sciences University, Portland 97201.
J Am Acad Dermatol. 1990 Dec;23(6 Pt 2):1280-5; discussion 1285-7. doi: 10.1016/0190-9622(90)70355-l.
Renal dysfunction is a frequent consequence of cyclosporine administration, even when cyclosporine blood concentrations are maintained within proper therapeutic levels. As dermatologic indications for this compound expand, it is important for clinicians to understand the relevant pharmacology and physiology that underlie cyclosporine-induced renal dysfunction. This article reviews the clinical pharmacology of cyclosporine, the principles of renal function testing, and the clinical manifestations of this drug's effects on the kidney. Sudden declines in kidney function, long-term cyclosporine nephrotoxicity, hemolytic-uremic syndrome, and hypertension are discussed from a clinical and experimental standpoint. Finally, practical suggestions are provided to aid the dermatologist in managing cyclosporine-treated patients.
即使环孢素的血药浓度维持在适当的治疗水平，肾功能不全仍是使用环孢素常见的后果。随着该化合物皮肤病学适应症的扩大，临床医生了解环孢素所致肾功能不全的相关药理学和生理学知识非常重要。本文综述了环孢素的临床药理学、肾功能检测原则以及该药物对肾脏影响的临床表现。从临床和实验角度讨论了肾功能的突然下降、长期环孢素肾毒性、溶血尿毒综合征和高血压。最后，提供了实用建议，以帮助皮肤科医生管理接受环孢素治疗的患者。
