Department of Pharmacology, UCL School of Pharmacy, 29-39 Brunswick Square, London WC1N 1AX, UK.
Brain Res. 2012 Dec 3;1487:192-7. doi: 10.1016/j.brainres.2012.03.069. Epub 2012 Jul 6.
Gap junctions between inhibitory neurones in cortical regions have been well documented over the years. However, although the presence of electrical coupling between pyramidal cells has been supported by dye-coupling and recordings of fast prepotentials called 'spikelets', direct evidence for such coupling remains sparse. Electrical coupling between pyramids has however been shown to play a significant role in oscillatory network activity, spatial exploration and learning and memory and full characterization of these synapses are overdue. In this review, an overview of the known properties of these electrical synapses is given, focusing on a study in the CA1 region of the hippocampus. This article is part of a Special Issue entitled Electrical Synapses.
多年来，人们已经很好地记录了皮质区域抑制性神经元之间的缝隙连接。然而，尽管已有染料偶联和快速前电位（称为“棘波”）记录支持锥体神经元之间存在电耦合，但这种耦合的直接证据仍然很少。然而，锥体神经元之间的电耦合已被证明在振荡网络活动、空间探索和学习记忆中发挥重要作用，因此对这些突触进行全面表征是必要的。在这篇综述中，概述了这些电突触的已知特性，重点介绍了海马 CA1 区的一项研究。本文是特刊“电突触”的一部分。
