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免疫原性与淋巴细胞3',5'-环磷酸腺苷依赖性蛋白激酶抑制作用的相关性。

Correlation of immunogenicity with suppression of lymphocyte adenosine 3',5'-monophosphate-dependent protein kinase.

作者信息

Hakim A A

出版信息

Experientia. 1979 Oct 15;35(10):1378-80. doi: 10.1007/BF01964019.

DOI:10.1007/BF01964019
PMID:227714
Abstract

Cyclic-AMP-dependent protein kinase activity was depressed in whole spleen as well as in isolated splenic lymphocytes from 3-methylcholanthrene (MCA), R3230 AdCa mammary adenocarcinoma, N-hydroxy-2-acetylaminofluorene, and 4-dimethylaminoazobenzene (DMAAB) tumor-bearing Fischer rats as compared to control animals. The magnitude of depression increased with the immunogenicity of the tumor. The depressed enzyme activity was the result of a reduced Vmax for adenosine 3',5'-monophosphate (cAMP)-stimulated histone phosphorylation.

摘要

与对照动物相比，来自患3-甲基胆蒽（MCA）、R3230 AdCa乳腺腺癌、N-羟基-2-乙酰氨基芴和4-二甲基氨基偶氮苯（DMAAB）肿瘤的Fischer大鼠的全脾以及分离的脾淋巴细胞中的环磷酸腺苷依赖性蛋白激酶活性降低。抑制程度随肿瘤的免疫原性增加而增加。酶活性降低是由于3',5'-单磷酸腺苷（cAMP）刺激的组蛋白磷酸化的Vmax降低所致。

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本文引用的文献

1
Cyclic AMP and the immune response;环磷酸腺苷与免疫反应；
Adv Cyclic Nucleotide Res. 1974;4(0):1-79.
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Regulation of adenosine 3',5'-monophosphate-dependent protein kinase. I. Preliminary characterization of the adipose tissue enzyme in crude extracts.3',5'-环磷酸腺苷依赖性蛋白激酶的调节。I. 粗提物中脂肪组织酶的初步特性
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Difference in the cyclic adenosine 3',5'-monophosphate levels in normal and transformed cells.正常细胞与转化细胞中环磷酸腺苷水平的差异。
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Cyclic AMP levels in fibroblasts: relationship to growth rate and contact inhibition of growth.成纤维细胞中环磷酸腺苷水平：与生长速率及生长接触抑制的关系
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Mechanism of action of BCG vaccine on neoplastic proliferation and host immune responses.卡介苗对肿瘤增殖和宿主免疫反应的作用机制。
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A rapid method for preparing Ficoll-hypaque step gradients and gradient overlays.一种制备Ficoll-泛影葡胺阶梯梯度和梯度覆盖物的快速方法。
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Action of Bacillus Calmette Guerin vaccine. II. Mechanisms to mount effective immune response against neoplastic proliferation.卡介苗的作用。II. 针对肿瘤增殖产生有效免疫反应的机制。
Pharm Acta Helv. 1976;51(4):98-105.