重新审视TFIIF在RNA聚合酶II转录起始中的作用。
Rethinking the role of TFIIF in transcript initiation by RNA polymerase II.
作者信息
Luse Donal S
机构信息
Lerner Research Institute, Cleveland, OH, USA.
出版信息
Transcription. 2012 Jul-Aug;3(4):156-9. doi: 10.4161/trns.20725. Epub 2012 Jul 1.
Abstract
TFIIF is considered to be a general transcription factor, based on the fact that it is essential for assembly of RNA polymerase II preinitiation complexes on fully double-stranded templates in vitro. Existing models assign various tasks to TFIIF during preinitiation complex formation and transcript initiation. Recent results do not support all aspects of those models but they do emphasize the significance of the interaction of TFIIF and TFIIB. Other recent findings raise the possibility that a fraction of RNA polymerase II transcription complex assembly proceeds through a pathway that is independent of TFIIF.
摘要
基于TFIIF在体外双链模板上对RNA聚合酶II起始前复合物组装至关重要这一事实，它被认为是一种通用转录因子。现有模型在起始前复合物形成和转录起始过程中赋予TFIIF各种任务。最近的结果并不支持这些模型的所有方面，但确实强调了TFIIF与TFIIB相互作用的重要性。其他最近的发现提出了一种可能性，即一部分RNA聚合酶II转录复合物的组装通过一条独立于TFIIF的途径进行。
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