Yoshioka T, Ando M, Taniguchi K, Yamasaki F, Motoyama H
Division of Obstetrics and Gynecology, Center for Adult Diseases, Kurashiki.
Nihon Sanka Fujinka Gakkai Zasshi. 1990 Dec;42(12):1634-40.
Recently particular interest has been shown in the relationship of the aging phenomenon to lipid peroxidation by free radicals. We studied changes in lipid peroxidation in the human placenta by measuring lipoperoxides from early pregnancy to term. In addition, we studied changes in the activities of superoxide dismutase, catalase, glutathione peroxidase and the concentration of alpha-tocopherol in the placental tissues. The degree of lipid peroxidation in placental tissue in early pregnancy was significantly higher than that in late pregnancy. Lipid peroxidation in the case of spontaneous abortion was slightly higher than that in normal pregnancy. The activities of SOD and catalase increased significantly, but glutathione peroxidase activity remained almost the same throughout development. On the other hand, the alpha-tocopherol concentration decreased gradually as gestation progressed. These results suggest that early placental tissue is functionally immature, then gradually suppresses lipoperoxide formation as pregnancy advances. The placental tissue protects the fetus from many kinds of radicals in the feto-maternal circulation.
最近，人们对衰老现象与自由基引发的脂质过氧化之间的关系表现出了特别的兴趣。我们通过测量从妊娠早期到足月的脂质过氧化物，研究了人胎盘脂质过氧化的变化。此外，我们还研究了胎盘组织中超氧化物歧化酶、过氧化氢酶、谷胱甘肽过氧化物酶的活性变化以及α-生育酚的浓度变化。妊娠早期胎盘组织中的脂质过氧化程度明显高于妊娠晚期。自然流产情况下的脂质过氧化略高于正常妊娠。超氧化物歧化酶和过氧化氢酶的活性显著增加，但谷胱甘肽过氧化物酶的活性在整个发育过程中几乎保持不变。另一方面，随着妊娠进展，α-生育酚浓度逐渐降低。这些结果表明，早期胎盘组织功能不成熟，随着妊娠进展逐渐抑制脂质过氧化物的形成。胎盘组织保护胎儿免受母婴循环中多种自由基的侵害。
