Department of Chemistry, National Taiwan Normal University, 88, Sec. 4, Tingchow Road, Taipei 11677, Taiwan, ROC.
Chem Commun (Camb). 2012 Aug 21;48(65):8135-7. doi: 10.1039/c2cc33972b. Epub 2012 Jul 9.
A general preparation of new types of benzofurans, benzothiophenes and indoles is realized via chemoselective intramolecular Wittig reactions with the corresponding ester, thioester and amide functionalities using in situ formed phosphorus ylides as key intermediates. The reaction conditions are very mild, and numerous Michael acceptors and commercially available acid chlorides can be applied very efficiently in a one-step procedure.
通过使用相应的酯、硫酯和酰胺官能团原位形成的磷叶立德作为关键中间体，实现了通过化学选择性分子内 Wittig 反应对新型苯并呋喃、苯并噻吩和吲哚的一般制备。反应条件非常温和，许多迈克尔受体和市售的酰氯可以在一步法中非常有效地应用。
