Yamazaki I, Shimizu F, Takeuchi S, Tanaka K, Oite T
Department of Obstetrics and Gynecology, Niigata University School of Medicine.
Nihon Sanka Fujinka Gakkai Zasshi. 1990 Dec;42(12):1685-90.
The charge-dependent materno-fetal barrier of near-term rats was examined with two pairs of radiolabelled proteins differently charged. When the proteins were injected intra-arterially, the maternal blood concentrations of the two cationized proteins (BSA and human IgG) exceeded those of native proteins in the chorioallantoic placenta and fetus during the period of examination (15-180 min). In the yolk sac placenta, these percentages were essentially the same as those of native proteins. Following intra-placental injection, the amounts of the cationized proteins in the chorioallantoic placenta and fetus were significantly (p less than 0.01) greater than those of native proteins at the particular times examined (5 and 60 min). In contrast, the amounts of cationized proteins in the yolk sac placenta were basically the same as those of native proteins. The data presented above indicate the charge on proteins that considerably influenced their materno-fetal transfer, particularly via the chorioallantoic placenta.
用两对带不同电荷的放射性标记蛋白质研究了近足月大鼠的电荷依赖性母胎屏障。当经动脉注射这些蛋白质时，在检查期间（15 - 180分钟），两种阳离子化蛋白质（牛血清白蛋白和人免疫球蛋白）在绒毛膜尿囊胎盘和胎儿中的母体血药浓度超过了天然蛋白质。在卵黄囊胎盘中，这些百分比与天然蛋白质基本相同。胎盘内注射后，在特定检查时间（5和60分钟），绒毛膜尿囊胎盘和胎儿中阳离子化蛋白质的量显著（p小于0.01）高于天然蛋白质。相比之下，卵黄囊胎盘中阳离子化蛋白质的量与天然蛋白质基本相同。上述数据表明蛋白质的电荷对其母胎转运有很大影响，尤其是通过绒毛膜尿囊胎盘的转运。
