Department of Neurosurgery, Bonn University, Germany.
J Neuropsychiatry Clin Neurosci. 2012 Spring;24(2):223-36. doi: 10.1176/appi.neuropsych.11080180.
The medial forebrain bundle (MFB), a key structure of reward-seeking circuitry, remains inadequately characterized in humans despite its vast importance for emotional processing and development of addictions and depression. Using Diffusion Tensor Imaging Fiber Tracking (DTI FT) the authors describe potential converging ascending and descending MFB and anterior thalamic radiation (ATR) that may mediate major brain reward-seeking and punishment functions. Authors highlight novel connectivity, such as supero-lateral-branch MFB and ATR convergence, caudally as well as rostrally, in the anterior limb of the internal capsule and medial prefrontal cortex. These anatomical convergences may sustain a dynamic equilibrium between positive and negative affective states in human mood-regulation and its various disorders, especially evident in addictions and depression.
内侧纵束（MFB）是寻求奖励回路的关键结构，尽管它对于情绪处理以及成瘾和抑郁的发展具有重要意义，但在人类中仍未得到充分描述。作者使用弥散张量成像纤维追踪（DTI FT）描述了潜在的会聚性上升和下降 MFB 以及前丘脑辐射（ATR），这些可能介导大脑主要的奖励寻求和惩罚功能。作者强调了新的连接，例如在内囊前肢和内侧前额叶皮质中，MFB 和 ATR 的超外侧分支在尾部以及头部的会聚。这些解剖学上的会聚可能在人类情绪调节及其各种障碍（尤其是成瘾和抑郁）中维持正负情感状态之间的动态平衡。
