Department of Psychiatry and Behavioral Neuroscience, University of Chicago Medical Center, Chicago, IL, USA.
J Neuropsychiatry Clin Neurosci. 2012 Spring;24(2):247-54. doi: 10.1176/appi.neuropsych.11070151.
Anti-NMDAR (N-methyl-d-aspartate receptor) encephalitis is a novel autoimmune and paraneoplastic disease often presenting as acute psychosis. Few studies exist in the psychiatric literature on neuroimmunity and behavioral management. This article reviews the epidemiology, diagnosis, pathophysiology, and management of this disease from a neuropsychiatric perspective. Patients have potential for near-complete recovery with early diagnosis and intervention. In addition to immune-suppression and tumor removal, electroconvulsive therapy may be an important tool in treatment of the underlying process in cases developing life-threatening catatonia. Psychiatrists should be familiar with treatment options, since they may be consulted within the context of a multispecialty team.
抗 N- 甲基-D-天冬氨酸受体（N-methyl-d-aspartate receptor）脑炎是一种新型自身免疫性和副肿瘤性疾病，常表现为急性精神病。在精神病学文献中，关于神经免疫和行为管理的研究很少。本文从神经精神病学的角度回顾了这种疾病的流行病学、诊断、病理生理学和治疗。早期诊断和干预可使患者有接近完全恢复的可能。除免疫抑制和肿瘤切除外，电惊厥治疗在治疗危及生命的紧张症时可能是治疗潜在过程的重要工具。精神科医生应该熟悉治疗选择，因为他们可能会在多学科团队的背景下被咨询。
