Jandu Amritpal S, Odor Peter M, Vidgeon Steven D
Intensive Care Department, Croydon University Hospital, Croydon, UK.
J Intensive Care Soc. 2016 Nov;17(4):346-352. doi: 10.1177/1751143716638371. Epub 2016 Mar 18.
Anti-N-methyl-D-aspartate receptor encephalitis is a recently recognised autoimmune, paraneoplastic syndrome that typically presents with psychiatric disturbance, reduced conscious level and seizures. The disorder has been previously associated with ovarian teratomas. We present the case of a 35-year-old female, with a previous surgical history for resection of an ovarian teratoma, who later developed status epilepticus and anti-N-methyl-D-aspartate receptor encephalitis requiring intensive care management. Her presentation, treatment and early follow-up are described, alongside an overview of anti-N-methyl-D-aspartate receptor encephalitis pathophysiology and intensive care management.
抗N-甲基-D-天冬氨酸受体脑炎是一种最近才被认识的自身免疫性副肿瘤综合征，通常表现为精神障碍、意识水平下降和癫痫发作。该疾病此前一直与卵巢畸胎瘤有关。我们报告了一例35岁女性病例，该患者既往有卵巢畸胎瘤切除手术史，后来发展为癫痫持续状态和抗N-甲基-D-天冬氨酸受体脑炎，需要重症监护治疗。本文描述了她的临床表现、治疗及早期随访情况，并概述了抗N-甲基-D-天冬氨酸受体脑炎的病理生理学及重症监护治疗。
