Department of Ophthalmology, Chung-Ang University, College of Medicine, Seoul, Korea.
Br J Ophthalmol. 2012 Sep;96(9):1222-6. doi: 10.1136/bjophthalmol-2011-301207. Epub 2012 Jul 6.
To evaluate the morphological features and prevalence of accompanying late age-related macular degeneration (AMD) according to the fundus distribution of reticular pseudodrusen (RPD).
According to the involved area in the fundus, the distribution of RPD was classified as localised, intermediate, or diffuse type. Morphology of RPD was classified as discrete, branching, or confluent pattern. The presence of late AMD was evaluated.
233 eyes of 121 patients with RPD were included. The distribution of RPD was localised, intermediate and diffuse type in 30.9%, 40.3% and 28.8% of eyes, respectively. The discrete, branching and confluent morphological patterns were found in 45.8%, 44.8% and 9.7% of the localised type, and in 0%, 13.8% and 86.2% of the intermediate type, respectively. In contrast, the diffuse type showed only the confluent morphological pattern. The prevalence of accompanying late AMD was 13.9%, 13.8% and 56.7% in the localised, intermediate and diffuse type, respectively, and it was significantly higher in the diffuse type (p<0.05).
RPD with diffuse distribution showed a confluent morphological pattern and a high prevalence of late AMD. RPD can be classified by the fundus distribution for the assessment of visual prognosis.
评估根据网状假性黄斑部萎缩（RPD）的眼底分布的形态特征和晚期年龄相关性黄斑变性（AMD）的患病率。
根据眼底受累面积，RPD 的分布分为局限性、中间型和弥漫型。RPD 的形态学分为离散型、分支型或融合型。评估晚期 AMD 的存在。
共纳入 121 例 233 只眼 RPD 患者。局限性、中间型和弥漫型 RPD 的眼底分布分别占 30.9%、40.3%和 28.8%。局限性 RPD 中分别有 45.8%、44.8%和 9.7%为离散型、分支型和融合型形态，中间型 RPD 中分别有 0%、13.8%和 86.2%为分支型和融合型形态，而弥漫型 RPD 仅表现为融合型形态。局限性、中间型和弥漫型 RPD 中晚期 AMD 的患病率分别为 13.9%、13.8%和 56.7%，弥漫型 RPD 明显更高（p<0.05）。
弥漫性分布的 RPD 表现为融合型形态，晚期 AMD 的患病率较高。RPD 可根据眼底分布进行分类，以评估视力预后。
