Cohen S Y, Dubois L, Tadayoni R, Delahaye-Mazza C, Debibie C, Quentel G
Centre Ophtalmologique d'Imagerie et de Laser, 11 Rue Antoine Bourdelle, 75015 Paris, France.
Br J Ophthalmol. 2007 Mar;91(3):354-9. doi: 10.1136/bjo.2006.101022. Epub 2006 Sep 14.
To investigate the prevalence of reticular pseudodrusen (RPD) in eyes of patients presenting with newly diagnosed choroidal neovascularisation (CNV) in age-related macular degeneration (AMD), and to analyse the association between RPD, age-related maculopathy (ARM) and AMD.
Two observational consecutive prospective series. In series 1, patients with AMD with newly diagnosed CNV were sampled to determine the incidence of RPD. Eyes with and without RPD were compared by the Mann-Whitney non-parametric test and Fisher's exact test for age, sex of patients, the eye involved and type of CNV. Series 2 comprised 100 patients referred for fundus photography, fluorescein and/or indocyanine green angiography, for whom pictures showed RPD. This second cohort was then selected from a larger group of patients.
Patients with newly diagnosed CNV in series 1 comprised 67 women and 33 men, aged 57-96 years (mean 79.5). CNV was "classic" (32 eyes), "occult" (41) or exhibited vascularised pigment epithelial detachment (PED, 11), retinal angiomatous proliferation (RAP) with or without PED (13), or haemorrhagic or fibrovascular scarring (3). In all, 24 (24%) eyes had RPD. The prevalence of RAP was significantly higher in eyes with RPD than in those without (p = 0.0128), despite the small number of patients with RAP. In series 2, 100 patients with RPD were enrolled in 3 months, and corresponded to 8% of the overall cases referred to our centre (Centre Ophtalmologique d'Imagerie et de Laser, Paris, France). There were 77 women and 23 men, aged 54-93 years (mean 79.2). Eyes with RPD (n = 155) usually exhibited signs of ARM or AMD, including soft drusen (101 eyes) and/or retinal pigment epithelium abnormalities (70), geographical atrophy (27) and/or CNV (61). In both studies, examination of blue-light fundus pictures was extremely helpful in diagnosing RPD.
RPD have a high prevalence among patients with AMD with newly diagnosed CNV (24% of cases). RPD were commonly associated with ARM or AMD. This study suggests that eyes with RPD could be classified as a phenotype of ARM.
研究年龄相关性黄斑变性（AMD）中初诊脉络膜新生血管（CNV）患者眼部网状假性玻璃膜疣（RPD）的患病率，并分析RPD、年龄相关性黄斑病变（ARM）与AMD之间的关联。
两个连续的观察性前瞻性系列研究。在系列1中，对初诊为CNV的AMD患者进行抽样，以确定RPD的发生率。采用Mann-Whitney非参数检验和Fisher精确检验，比较有无RPD患者的年龄、性别、患眼及CNV类型。系列2包括100例因眼底照相、荧光素和/或吲哚菁绿血管造影前来就诊的患者，其照片显示有RPD。该第二队列是从一大组患者中选取的。
系列1中初诊为CNV的患者包括67名女性和33名男性，年龄57 - 96岁（平均79.5岁）。CNV为“典型性”（32只眼）、“隐匿性”（41只眼）或表现为血管化色素上皮脱离（PED，11只眼）、伴有或不伴有PED的视网膜血管瘤样增生（RAP，13只眼），或出血或纤维血管瘢痕形成（3只眼）。共有24只眼（24%）有RPD。尽管RAP患者数量较少，但有RPD的眼中RAP的患病率显著高于无RPD的眼（P = 0.0128）。在系列2中，3个月内纳入了100例有RPD的患者，占转诊至我们中心（法国巴黎眼科影像与激光中心）的所有病例的8%。有77名女性和23名男性，年龄54 - 93岁（平均79.2岁）。有RPD的眼（n = 155）通常表现出ARM或AMD的体征，包括软性玻璃膜疣（101只眼）和/或视网膜色素上皮异常（70只眼）、地图样萎缩（27只眼）和/或CNV（61只眼）。在两项研究中，蓝光眼底照片检查对诊断RPD非常有帮助。
在初诊为CNV的AMD患者中，RPD的患病率较高（24%的病例）。RPD通常与ARM或AMD相关。本研究表明，有RPD的眼可归类为ARM的一种表型。
