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自身免疫性疾病背景下原发性放疗治疗胃黏膜相关淋巴组织淋巴瘤。

Gastric MALT lymphoma treated with primary radiotherapy in the setting of autoimmune disease.

机构信息

Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

出版信息

J Natl Compr Canc Netw. 2012 Jul 1;10(7):815-9. doi: 10.6004/jnccn.2012.0085.

DOI:10.6004/jnccn.2012.0085
PMID:22773797
Abstract

Autoimmune and microbial-induced immune reactions are associated with lymphomagenesis, particularly of extranodal marginal zone B-cell lymphomas. This report presents a case of Helicobacter pylori-negative gastric extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) in the setting of Sjögren syndrome and Hashimoto thyroiditis treated with primary involved-field radiotherapy. This report describes etiologic data, diagnostic and treatment considerations, and sophisticated radiation therapy techniques aimed at reducing long-term toxicity in this indolent disease.

摘要

自身免疫和微生物引起的免疫反应与淋巴瘤的发生有关,尤其是结外边缘区 B 细胞淋巴瘤。本报告介绍了一例 Sjögren 综合征和桥本甲状腺炎合并幽门螺杆菌阴性胃黏膜相关淋巴组织结外边缘区淋巴瘤(MALT 淋巴瘤)的病例,采用累及野放疗进行治疗。本报告描述了病因数据、诊断和治疗注意事项,以及旨在降低这种惰性疾病长期毒性的复杂放射治疗技术。

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