Alves Cresio, Silva Sheila Ferreira
Pediatric Endocrinology Unit, Faculty of Medicine, Hospital Universitario Professor Edgard Santos, Federal University of Bahia, Salvador, Bahía, Brazil.
J Pediatr Endocrinol Metab. 2012;25(3-4):323-5. doi: 10.1515/jpem-2011-0472.
We report a long-term follow-up on the use of anastrozole in the treatment of peripheral precocious puberty (PP) in McCune-Albright syndrome (MAS). A girl, age 3 years and 9 months, was diagnosed with MAS due to PP, café-au-lait spots, and polyostotic fibrous dysplasia. Serum estradiol was elevated, and gonadotropins were suppressed. Pelvic ultrasound showed an enlarged uterus and a follicle cyst (13 mm) in the left ovary. Bone scintigraphy showed osteogenic lesions on the skull, humerus, tibia, and acetabulum. Bone age was 3 years and 5 months at the chronological age of 3 years. After 36 months of treatment with anastrozole (1 mg/day), there was suppression of breast growth, normalization of growth velocity and serum estradiol, and disappearance of ovarian cysts. However, there was increase in uterine volume, advancement of bone age, and two episodes of vaginal bleeding (18th and 24th months). This report shows the partial benefit of anastrozole in the treatment of peripheral PP of girls with MAS.
我们报告了阿那曲唑治疗McCune-Albright综合征（MAS）所致外周性性早熟（PP）的长期随访情况。一名3岁9个月的女孩因PP、咖啡牛奶斑和多骨型纤维发育不良被诊断为MAS。血清雌二醇升高，促性腺激素被抑制。盆腔超声显示子宫增大，左侧卵巢有一个卵泡囊肿（13毫米）。骨闪烁显像显示颅骨、肱骨、胫骨和髋臼有骨生成病变。实际年龄3岁时骨龄为3岁5个月。在用阿那曲唑（1毫克/天）治疗36个月后，乳房生长受到抑制，生长速度和血清雌二醇恢复正常，卵巢囊肿消失。然而，子宫体积增大，骨龄提前，并有两次阴道出血（第18个月和第24个月）。本报告显示了阿那曲唑在治疗MAS女孩外周性PP中的部分益处。
