Sakai K
Second Department of Surgery, School of Medicine, Ehime University.
Nihon Shokakibyo Gakkai Zasshi. 1990 Nov;87(11):2473-82.
We have conducted an experiment to examine the effects of a truncal vagotomy on the gallstone formation. Chosen for this experiment were ICR male mice that were given an abdominal vagotomy. While the postoperated mice were on a cholesterol-free diet, we found that, due to the vagotomy, the mole fraction of the cholesterol in the mice's gallbladder bile increased, as did the total protein concentration in their bile. When being fed foods to promoted a gallstone, the postoperated mice clearly demonstrated a higher rate of gallstones formation than without the vagotomy, and while the cholesterol concentration in their bile did not show a significant increase, total protein concentration did increase significantly. The rate of a biliary infection also increased. Considering the above, we have concluded that a truncal vagotomy is a factor that promotes the gallstone formation.
我们进行了一项实验，以研究迷走神经干切断术对胆结石形成的影响。本实验选用接受腹部迷走神经切断术的ICR雄性小鼠。在术后小鼠食用无胆固醇饮食时，我们发现，由于迷走神经切断术，小鼠胆囊胆汁中胆固醇的摩尔分数增加，胆汁中的总蛋白浓度也增加。当给术后小鼠喂食促进胆结石形成的食物时，与未进行迷走神经切断术的小鼠相比，术后小鼠明显表现出更高的胆结石形成率，并且虽然它们胆汁中的胆固醇浓度没有显著增加，但总蛋白浓度却显著增加。胆道感染率也增加了。考虑到上述情况，我们得出结论，迷走神经干切断术是促进胆结石形成的一个因素。
