Bekele Tsegaye, Rourke Sean B, Tucker Ruthann, Greene Saara, Sobota Michael, Koornstra Jay, Monette Laverne, Rueda Sergio, Bacon Jean, Watson James, Hwang Stephen W, Dunn James, Guenter Dale
The Ontario HIV Treatment Network, Toronto, Canada.
AIDS Care. 2013;25(3):337-46. doi: 10.1080/09540121.2012.701716. Epub 2012 Jul 9.
Research has established a link between perceived social support and health-related quality of life (HRQOL) among persons living with HIV/AIDS. However, little is known about the ways through which social support influences HRQOL. This study examined the direct and indirect effects of perceived social support on physical and mental HRQOL in a sample of 602 adults living with HIV in Ontario, Canada. Participants completed the Medical Outcomes Study-HIV (MOS-HIV) health survey, the MOS-HIV Social Support Scale (MOS-HIV-SSS), and the Center for Epidemiological Studies Depression-Revised scale. Data on demographic and clinical characteristics were also collected. The direct and indirect effects of social support on the two MOS-HIV HRQOL summary measures, that is, physical health summary (PHS) and mental health summary (MHS), were estimated in multiple linear regression analyses. Perceived social support had significant direct effects on PHS (B=0.04, p<0.01) and MHS (B=0.05, p<0.01). It also had significant indirect effect on both PHS (B=0.04, p<0.01) and MHS (B=0.11, p<0.01), mediated by depressive symptoms. Interventions that enhance social support have the potential to contribute to better HRQOL either directly or indirectly by decreasing the deleterious effect of depressive symptoms on HRQOL.
研究已证实，在感染艾滋病毒/艾滋病的人群中，感知到的社会支持与健康相关生活质量（HRQOL）之间存在联系。然而，对于社会支持影响健康相关生活质量的方式，我们知之甚少。本研究调查了加拿大安大略省602名感染艾滋病毒的成年人样本中，感知到的社会支持对身心健康相关生活质量的直接和间接影响。参与者完成了医疗结果研究-艾滋病毒（MOS-HIV）健康调查、MOS-HIV社会支持量表（MOS-HIV-SSS）以及流行病学研究中心抑郁修订量表。还收集了人口统计学和临床特征数据。在多元线性回归分析中，估计了社会支持对两个MOS-HIV健康相关生活质量综合指标，即身体健康综合指标（PHS）和心理健康综合指标（MHS）的直接和间接影响。感知到的社会支持对身体健康综合指标（B = 0.04，p < 0.01）和心理健康综合指标（B = 0.05，p < 0.01）有显著直接影响。它对身体健康综合指标（B = 0.04，p < 0.01）和心理健康综合指标（B = 0.11，p < 0.01）也有显著间接影响，以抑郁症状为中介。增强社会支持的干预措施有可能通过降低抑郁症状对健康相关生活质量的有害影响，直接或间接地促进更好的健康相关生活质量。
